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Combination therapy with cyclosporine A and anti-TNF-α agents in the treatment of rheumatoid arthritis and concomitant hepatitis C virus infection

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Abstract

We describe two cases of rheumatoid arthritis (RA) patients and concomitant hepatitis C virus infection (HCV), treated with cyclosporine A (CsA) and anti-TNF-α agents. SGOT/SGPT and HCV-RNA serum levels remained unchanged longer than 1 year of treatment. No side effects were registered. We suggest that combination therapy with CsA and TNF-α blockers should be considered safe and well-tolerated in the treatment of HCV-positive RA patients.

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Authors and Affiliations

  1. Dipartimento Medicina Clinica e Scienze Immunologiche, Policlinico Le Scotte, U.O.C. Reumatologia, Viale Bracci, 53100, Siena, Italy

    Francesca Bellisai, Chiara Giannitti, Alessandro Donvito & Mauro Galeazzi

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  1. Francesca Bellisai
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  2. Chiara Giannitti
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  3. Alessandro Donvito
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  4. Mauro Galeazzi
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Correspondence to Mauro Galeazzi.

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Bellisai, F., Giannitti, C., Donvito, A. et al. Combination therapy with cyclosporine A and anti-TNF-α agents in the treatment of rheumatoid arthritis and concomitant hepatitis C virus infection. Clin Rheumatol 26, 1127–1129 (2007). https://doi.org/10.1007/s10067-006-0412-1

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  • DOI: https://doi.org/10.1007/s10067-006-0412-1

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