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Lupus arthropathy: historical evolution from deforming arthritis to rhupus

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Abstract

Systemic lupus erythematosus is an autoimmune and inflammatory disease with multiple clinical manifestations, including arthropathy. The clinical presentation of articular involvement is variable, ranging from arthralgia without erosions or deformity to an erosive arthropathy and severe functional disability. A subset of patients with this articular involvement have Jaccoud’s arthropathy, and others have an arthropathy with clinical findings similar to rheumatoid arthritis that has been called “rhupus.” In this paper we review the historical evolution of concepts of lupus arthropathy, from deforming arthritis to rhupus, and conclude that rhupus is not a combination of rheumatoid arthritis and lupus. Instead, rhupus arthropathy should be regarded as a variant of the arthropathy of systemic lupus erythematosus.

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References

  1. Kaposi M (1892) Neue Beiträge zur Kenntnis des Lupus erythematosus. Arch Dermatol Syph 4:36–79

    Google Scholar 

  2. Osler W (1895) On the visceral complications of erythema exudativum multiforme. Am J Med Sci 110:629–646

    Google Scholar 

  3. Sequeira JH, Balean H (1902) Lupus erythematosus: a clinical study of seventy-one cases. Br J Dermatol 14:367–379

    Google Scholar 

  4. Jadassohn H (1904) Mracek’s Handbuch der Hautkrankheiten, vol III. Berlin, pp 298–424

  5. Libman E, Sacks B (1924) Hitherto undescribed form of valvular and mural endocarditis. Arch Intern Med 33:701–737

    Google Scholar 

  6. Tremaine JM (1934) Subacute Pick’s disease. Polyserositis with polyarthritis and glomerulonephritis: a report of two fatal cases. N Engl J Med 211:754–759

    Google Scholar 

  7. Friedberg CK, Gross L, Wallace K (1936) Non-bacterial thrombotic endocarditis associated with prolonged fever, arthritis, inflammations of serous membranes, and widespread vascular lesions. Arch Int Med 58:662

    Google Scholar 

  8. Keil H (1937) Conception of lupus erythematosus. Arch Dermatol 36:729–757

    Google Scholar 

  9. Slocumb CS (1940) Arthralgia and arthritis of lupus erythematosus. Proc Staff Med Mayo Clinic 15:683–686

    Google Scholar 

  10. Rose E, Pillsbury D (1944) Lupus erythematosus (erythematodes) and ovarian function: observation on a possible relationship, with report of six cases. Ann Intern Med 21:1022–1034

    Google Scholar 

  11. Daugherty GW, Baggenstoss AH (1950) Syndrome characterized by glomerulonephritis and arthritis. Ann Intern Med 85:900–923

    Google Scholar 

  12. Shearn MA, Pirofsky B (1952) Disseminated lupus erythematosus. Ann Intern Med 90:790–807

    CAS  Google Scholar 

  13. Dubois E (1953) Simplified method for the LE cell test. Ann Intern Med 92:168–184

    CAS  Google Scholar 

  14. Haserick JR (1955) Modern concepts of systemic lupus erythematosus. A review of 126 cases. J Chron Dis 317–334

  15. Zvaifler N (1962) Chronic post-rheumatic fever (Jaccoud’s) arthritis. N Engl J Med 267:10–15

    Google Scholar 

  16. Bywaters EG (1975) Jaccoud’s syndrome: a sequel to the joint involvement of systemic lupus erythematosus. Clin Rheum Dis 1:125–148

    Google Scholar 

  17. Kramer LS, Ruderman JE, Dubois E, Friou G (1970) Deforming non-erosive arthritis of the hands in chronic systemic lupus erythematosus. Arthritis Rheum 13:329–339

    Google Scholar 

  18. Morley KD, Leung A, Raynes R (1982) Lupus foot. BMJ 284:557–558

    CAS  Google Scholar 

  19. Mitzutani W, Quismorio A (1984) Lupus foot: deforming lupus erythematosus. J Rheumatol 11:80–82

    PubMed  Google Scholar 

  20. Reilly PA, Evison G (1990) Arthropathy of the hand deformities in systemic lupus erythematosus. Hand Surg 17:777–784

    CAS  Google Scholar 

  21. De la Sota M, García-Morteo O, Maldonado-Cocco JA (1985) Jaccoud’s arthropathy of the knee in SLE. Arthritis Rheum 28:825–827

    PubMed  Google Scholar 

  22. Armas-Cruz R, Harnecker J, Ducach G, Jalil J (1958) Clinical diagnosis of systemic lupus erythematosus. Am J Med 25:409–419

    Article  CAS  PubMed  Google Scholar 

  23. Noonan CD, Odone DT, Englemann EP, Splitter SD (1963) Roentgenographic manifestations of joint disease in systemic lupus erythematosus. Radiology 80:837–843

    CAS  PubMed  Google Scholar 

  24. Dubois E, Tuffanelli D (1964) The improving prognosis of systemic lupus erythematosus (SLE): a computer analysis of 520 cases. JAMA 190:104–112

    CAS  PubMed  Google Scholar 

  25. Molina JF, Molina J, Gutiérrez S, García C, Ristea R, Espinoza L (1995) Deforming arthropathy of the hands (Jaccoud’s) in SLE: an independent subset of SLE (abstract)? Arthritis Rheum 38:5347

    Google Scholar 

  26. Alarcón-Segovia D, Abud-Mendoza C, Iglesias-Gamarra A (1988) Deforming arthropathy of the hands in systemic lupus erythematosus. J Rheumatol 15:65–69

    PubMed  Google Scholar 

  27. Girgis FL, Popple A, Brucker F (1978) Jaccoud’s arthropathy: a case report and necropsy study. Ann Rheum Dis 37:561–565

    CAS  PubMed  Google Scholar 

  28. Manthorpe R, Bendixed G, Schioler H, Viderbal A (1980) Jaccoud’s syndrome: a nosographic entity associated with SLE. J Rheumatol 7:169–177

    CAS  PubMed  Google Scholar 

  29. Leskinen R, Skinifvers B, Laasonen L, Edgren K (1984) Bone lesions in SLE. Radiology 153:349–352

    CAS  PubMed  Google Scholar 

  30. Klemp P, Majoos F, Chalton D (1987) Articular mobility in SLE. Clin Rheumatol 6:202–207

    CAS  PubMed  Google Scholar 

  31. Laasonen L, Gripenberg R, Leskinen R, Skrifvars B, Edgren J (1990) A subset of SLE with progressive cystic bone lesions. Ann Rheum Dis 49:118–120

    CAS  PubMed  Google Scholar 

  32. Francheschini F, Cretti L, Quinzanini M, Rizzine F, Cattaneo R (1993) Deforming arthropathy of the hands in SLE is associated with antibodies to SSA/Ro and SSB/La. Lupus 3:419–422

    Google Scholar 

  33. Schumacher HR (1978) Electron microscopic study of synovial fluid cells in systemic lupus erythematosus. Arthritis Rheum 21:590

    Google Scholar 

  34. Edelman CM, Kunkel H, Franklin E (1958) Interaction of the rheumatoid factor with antigen-antibody complexes and gamma globulin. J Exp Med 108:105–120

    Article  CAS  PubMed  Google Scholar 

  35. Hassfeld W, Steiner G, Harmuth K (1989) Demonstration of a new antinuclear antibody (anti-RA 33) that is highly specific for rheumatoid arthritis. Arthritis Rheum 32:1515–1520

    CAS  PubMed  Google Scholar 

  36. Isenberg D, Steiner G, Smolen J (1994) Clinical utility and serological connections of anti-RA 33 antibodies in systemic lupus erythematosus. J Rheumatol 21:1260–1263

    CAS  PubMed  Google Scholar 

  37. Richter Cohen M, Steiner G, Smolen J (1998) Erosive arthritis in systemic lupus erythematosus: analysis of a distinct clinical and serological subset. Br J Rheumatol 37:421–424

    Article  PubMed  Google Scholar 

  38. Toone E, Irby R, Pierce EL (1960) The LE cell in rheumatoid arthritis. Am J Med Sci 240:599–608

    PubMed  Google Scholar 

  39. Kantor GL, Bickel YB, Barnett EV (1969) Coexistence of systemic lupus erythematosus and rheumatoid arthritis: report of a case and review of the literature, with clinical, pathological and serologic observations. Am J Med 47:433–444

    Article  CAS  PubMed  Google Scholar 

  40. Hahn BH, Yardley JH, Stevens MB (1970) “Rheumatoid” nodules in systemic lupus erythematosus. Ann Intern Med 72:49–58

    CAS  Google Scholar 

  41. Schur PH (1971) Systemic lupus erythematosus. In: Beeson PB, McDermott W (eds) Cecil-Loeb textbook of medicine, 13th edn. Saunders, Philadelphia, p 821

  42. Simón JA, Granados J, Cabiedes J, Ruíz Morals J, Alcocer J (2002) Clinical and immunogenetic characterization of Mexican patients with “Rhupus”. Lupus 11:287–292

    Article  PubMed  Google Scholar 

  43. Fernández A, Quintana G, Restrepo JF, Rondon F, Sánchez A, Iglesias-Gamarra A (2003) Artropatía lupica: rhupus, artropatía de Jaccoud, artropatía erosiva asociada al anti-RA 33, variantes de la artropatía lúpica? Revisión de una serie de casos. Rev Colomb Reumatol 10:164–170

    Google Scholar 

  44. Cohen AS, Reynolds WE, Franklin EC, Kulka JP, Ropes MW, Shulman LE, Wallace SL (1971) Preliminary criteria for the classification of systemic lupus erythematosus. Bull Rheum Dis21:643–648

    Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Rheumatology Unit, Universidad Nacional de Colombia, Bogota, Colombia

    Andrés Fernández, Gerardo Quintana, José Félix Restrepo, Federico Rondón, Álvaro Sánchez & Antonio Iglesias

  2. Division of Rheumatology, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA

    Eric L. Matteson

Authors
  1. Andrés Fernández
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  2. Gerardo Quintana
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  3. Eric L. Matteson
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  4. José Félix Restrepo
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  5. Federico Rondón
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  6. Álvaro Sánchez
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  7. Antonio Iglesias
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Correspondence to Eric L. Matteson.

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Fernández, A., Quintana, G., Matteson, E.L. et al. Lupus arthropathy: historical evolution from deforming arthritis to rhupus. Clin Rheumatol 23, 523–526 (2004). https://doi.org/10.1007/s10067-004-0951-2

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  • DOI: https://doi.org/10.1007/s10067-004-0951-2

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