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Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis

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Abstract

Pulmonary toxicity and blood dyscrasias are rare side effects of sulfasalazine. Pulmonary pathology is variable, the most common being eosinophilic pneumonia with peripheral eosinophilia, and interstitial inflammation with or without fibrosis. We here present the case of a 68-year-old female patient treated for 6 months with sulfasalazine for rheumatoid arthritis. On laboratory examination, eosinophil count was 97×103 mm3. Thorocoscopic biopsy was performed . Histopathologic diagnosis was bronchiolitis obliterans organizing pneumonia (BOOP). This is the first case in the literature to present with sulfasalazine-induced BOOP in a patient with seronegative RA.

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Abbreviations

BOOP:

Bronchiolitis obliterans organizing pneumonia

DMARS:

Disease-modifying antirheumatic drugs

RA:

Rheumatoid arthritis

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Authors and Affiliations

  1. Department of Chest Disease, Faculty of Medicine, Mersin University, Koy-Tür (2) Sitesi, B(2) Blok, Daire 4, D.Tepe, 33320, Mersin, Turkey

    Bahar Ulubaş & Eylem Özgür

  2. Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Mersin University, Mersin, Turkey

    Günşah Şahin

  3. Department of Radiology, Faculty of Medicine, Mersin University, Mersin, Turkey

    Caner Özer & Demir Apaydın

  4. Department of Pathology, Faculty of Medicine, Mersin University, Mersin, Turkey

    Özlem Aydın

Authors
  1. Bahar Ulubaş
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  2. Günşah Şahin
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  3. Caner Özer
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  4. Özlem Aydın
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  5. Eylem Özgür
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  6. Demir Apaydın
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Correspondence to Bahar Ulubaş.

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Ulubaş, B., Şahin, G., Özer, C. et al. Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis. Clin Rheumatol 23, 249–251 (2004). https://doi.org/10.1007/s10067-003-0848-5

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  • DOI: https://doi.org/10.1007/s10067-003-0848-5

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