Abstract
Chronic recurrent multifocal osteomyelitis is a rare chronic inflammatory musculoskeletal process observed in children and young adults. Recently, the acronym SAPHO syndrome (for synovitis, acne, pustulosis, hyperostosis, osteitis) was coined to emphasise the association between osteo-articular inflammations and different skin abnormalities which are aseptic and filled with neutrophils. In adults, chronic recurrent multifocal osteomyelitis is now a classical manifestation of SAPHO syndrome. Chronic skin disorders were seen in eight of ten children on follow-up at the University Children's Hospitals in Bern and Zurich and in 61 of 260 paediatric cases reported in the literature. The different skin lesions were palmoplantar pustulosis (n=40), non-palmoplantar pustulosis (n=6), psoriasis vulgaris (n=16) or severe acne (n=4). More rarely Sweet syndrome (n=2) or pyoderma gangrenosum (n=1) were reported.
Conclusion The synovitis, acne, pustulosis, hyperostosis, osteitis syndrome is pertinent even in paediatrics since skin involvement is frequent.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 13 October 1999 and in revised form: 19 January 2000 / Accepted: 16 February 2000
Rights and permissions
About this article
Cite this article
Beretta-Piccoli, B., Sauvain, M., Gal, I. et al. Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in childhood: a report of ten cases and review of the literature. Eur J Pediatr 159, 594–601 (2000). https://doi.org/10.1007/s004310000500
Issue Date:
DOI: https://doi.org/10.1007/s004310000500