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Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus

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Abstract

Inappropriate activation of innate immune mechanisms, in particular of the type I interferon (IFN) system, is regarded to play an important role in the pathogenesis of lupus erythematosus (LE). Type I IFN serum levels have been shown to correlate with the disease activity in systemic LE and additionally play a proinflammatory role in the development of LE skin lesions. Recent studies demonstrated a close morphological association between the expression pattern of IFN-inducible chemokines (MxA, CXCL10) and typical histological features of cutaneous LE. These and other studies suggest that a complex network of IFN-associated cytokines, chemokines and adhesion molecules orchestrates and promotes tissue injury observed in LE skin.

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The authors have no potential conflict of interest.

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Authors and Affiliations

  1. Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany

    Joerg Wenzel, Sabine Zahn, Thomas Bieber & Thomas Tüting

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  1. Joerg Wenzel
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  2. Sabine Zahn
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  3. Thomas Bieber
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  4. Thomas Tüting
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Correspondence to Joerg Wenzel.

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Wenzel, J., Zahn, S., Bieber, T. et al. Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus. Arch Dermatol Res 301, 83–86 (2009). https://doi.org/10.1007/s00403-008-0892-8

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  • DOI: https://doi.org/10.1007/s00403-008-0892-8

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