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Frühsymptome der Dermatomyositis und des Antisynthetase-Syndroms

Early symptoms of dermatomyositis and antisynthetase syndrome

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Zusammenfassung

Einleitung

In den letzten Jahren wird die Früherkennung rheumatologischer Erkrankungen zunehmend wichtiger. Dies trifft insbesondere auch für die inflammatorischen Myopathien zu, die als Multisystemerkrankungen mit Beteiligung innerer Organe durch eine hohe Morbidität und Mortalität gekennzeichnet sind. Eine frühe Diagnosestellung vor Entwicklung irreversibler Organmanifestationen ist daher von großer Bedeutung.

Methoden

Der vorliegende Beitrag erläutert Frühzeichen der Dermatomyositis (DM) und des Antisynthetase-Syndroms und diskutiert Screeningmethoden, die eine frühe Diagnosestellung auch hinsichtlich einer Beteiligung innerer Organe erlauben. Darüber hinaus werden klinisch-serologische Subtypen und deren Bedeutung für die Prognoseabschätzung beschrieben.

Abstract

Introduction

The early diagnosis of rheumatic diseases is becoming increasingly important. This particularly includes inflammatory myopathies which are multisystemic disorders with visceral involvement that are associated with high morbidity and mortality. Early diagnosis before the development of irreversible organ involvement is, therefore, of great importance.

Methods

This report provides information on early signs and symptoms of dermatomyositis and antisynthetase syndrome. Furthermore, screening methods which allow early diagnosis including involvement of internal organs are discussed. In addition, clinical and serological subtypes and their impact on prognosis are described.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. B. Maurer gibt an, dass kein Interessenskonflikt besteht.

Dieser Beitrag enthält keine Studien an Menschen oder Tieren.

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Maurer, B. Frühsymptome der Dermatomyositis und des Antisynthetase-Syndroms. Z. Rheumatol. 72, 970–976 (2013). https://doi.org/10.1007/s00393-013-1196-8

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