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Reliability and responsiveness of the Juvenile Arthritis MRI Scoring (JAMRIS) system for the knee

  • Pediatric
  • Published:
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Abstract

Objectives

To assess the reliability and responsiveness of a new Juvenile Arthritis MRI Scoring (JAMRIS) system for evaluating disease activity of the knee.

Methods

Twenty-five juvenile idiopathic arthritis (JIA) patients with clinical knee involvement were studied using open-bore 1-T MRI. MRI features of synovial hypertrophy, bone marrow changes, cartilage lesions and bone erosions were independently scored by five readers using the JAMRIS system. In addition, the JAMRIS system was determined to be a follow-up parameter by two readers to evaluate the response to therapy in 15 consecutive JIA patients.

Results

Inter-reader (ICCs 0.86–0.95) and intra-reader reliability (ICCs 0.92–1.00) for the scoring of JAMRIS features was good. Reliability of the actual scores and changes in scores over time was good for all items: ICCs 0.89–1.00, 0.87–1.00, respectively. Concerning therapy response, the mean synovial hypertrophy scores decreased significantly (mean 1.1 point; P < 0.001, SRM = −0.65). No change was observed with respect to bone marrow change, cartilage lesion and bone erosion scores.

Conclusions

The JAMRIS proved to be a simple and highly reliable assessment score in the evaluation of JIA disease activity of the knee. The JAMRIS system may serve as an objective and accurate outcome measure in future research and clinical trials.

Key Points

• MRI is increasingly used to diagnose and assess juvenile idiopathic arthritis.

• A simple and reliable scoring method would help monitor progress and research.

• The Juvenile Arthritis MRI Scoring (JAMRIS) system provides reliable objective measures.

• JAMRIS evaluates synovial hypertrophy, bone marrow changes, cartilage lesions and bone erosions.

• The JAMRIS system can detect therapeutic response and should help future research.

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Acknowledgments

A research grant was received from the Reumafonds, Dutch Arthritis Association (Amsterdam, The Netherlands). The Dutch Arthritis Association was not involved in designing and conducting this study, did not have access to the data, and was not involved in data analysis or preparation of this manuscript.

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Authors and Affiliations

  1. Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

    Robert Hemke, Maaike P. Terra, Eline E. Deurloo & Mario Maas

  2. Department of Paediatric Haematology, Immunology, Rheumatology and Infectious Disease, Emma Children’s Hospital AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

    Robert Hemke, Marion A. J. van Rossum, Mira van Veenendaal, J. Merlijn van den Berg & Taco W. Kuijpers

  3. Department of Paediatric Rheumatology, Reade, Dr. Jan van Breemenstraat 2, Amsterdam, The Netherlands

    Marion A. J. van Rossum, J. Merlijn van den Berg & Koert M. Dolman

  4. Department of Radiology, Zuwe Hofpoort Hospital, Polanerbaan 2, Woerden, The Netherlands

    Milko C. de Jonge

  5. Department of Paediatric Rheumatology, St. Lucas Andreas Hospital, Jan Tooropstraat 164, Amsterdam, The Netherlands

    Koert M. Dolman

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  1. Robert Hemke
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  2. Marion A. J. van Rossum
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Correspondence to Robert Hemke.

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Hemke, R., van Rossum, M.A.J., van Veenendaal, M. et al. Reliability and responsiveness of the Juvenile Arthritis MRI Scoring (JAMRIS) system for the knee. Eur Radiol 23, 1075–1083 (2013). https://doi.org/10.1007/s00330-012-2684-y

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  • DOI: https://doi.org/10.1007/s00330-012-2684-y

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