Abstract
The aim of this study was to determine the clinical characteristics of Behcet’s disease (BD) complicated with malignancy in Korea. Of 1,769 patients with BD in our hospital, 32 patients (1.8%, 21 in solid cancer, 11 in hematologic malignancy) developed cancer. In 10 of the 32 subjects (31.3%), malignancy was diagnosed before or concomitantly with BD. Twelve cases (37.5%) occurred within the first 2 years of disease and 9 cases (28.1%) occurred 5 years after the diagnosis of BD. Myelodysplastic syndrome (MDS) was the most common disease (n = 7) followed by thyroid cancer (n = 4), breast cancer, cervix cancer, stomach cancer, rectal cancer, hepatoma, aplastic anemia (n = 3, each), renal cell cancer, endometrial cancer, lymphoma (n = 1, each). There were no significant differences in the clinical characteristic between patients with or without malignancy. Intestinal involvement were more frequent in patients with malignancy than those without, but was not statistically significant (p = 0.083). Our results demonstrate that MDS and thyroid cancer are the most common hematologic disease and solid cancer associated with BD, respectively. Further studies will be required to ascertain the pathogenic link between BD and malignancy and the prevalence of malignancy in BD.
References
Sakane T, Takeno M, Suzuki N, Inaba G (1999) Behcet’s disease. N Engl J Med 341:1284–1291
Abu-Shakra M, Guillemin F, Lee P (1993) Cancer in systemic sclerosis. Arthritis Rheum 36:460–464
Abu-Shakra M, Gladman DD, Urowitz MB (1996) Malignancy in systemic lupus erythematosus. Arthritis Rheum 39:1050–1054
Hill CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, Evans SR, Felson DT (2001) Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet 357:96–100
Pankhurst T, Savage CO, Gordon C, Harper L (2004) Malignancy is increased in ANCA-associated vasculitis. Rheumatology (Oxford) 43:1532–1535
Cengiz M, Altundag MK, Zorlu AF, Gullu IH, Ozyar E, Atahan IL (2001) Malignancy in Behcet’s disease: a report of 13 cases and a review of the literature. Clin Rheumatol 20:239–244
Kural-Seyahi E, Fresko I, Seyahi N, Ozyazgan Y, Mat C, Hamuryudan V, Yurdakul S, Yazici H (2003) The long-term mortality and morbidity of Behcet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center. Medicine (Baltimore) 82:60–76
Kaklamani VG, Tzonou A, Kaklamanis PG (2005) Behcet’s disease associated with malignancies. Report of two cases and review of the literature. Clin Exp Rheumatol 23:S35–S41
Bozi E, Katoulis AC, Stavrianeas NG (2007) Association of Behcet’s disease with hematologic malignancies. Int J Dermatol 46:333–334
Criteria for diagnosis of Behcet’s disease (1990) International Study Group for Behcet’s Disease. Lancet 335:1078–1080
Kaklamani VG, Sadim M, Koumantaki Y, Kaklamanis P, Pasche B (2008) Role of polymorphisms in adamantiades—Behcet’s disease. J Rheumatol 35:2376–2378
Shin HR, Jung KW, Won YJ, Park JG, 139 KCCR-affiliated Hospitals (2004) 2002 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 139 Hospitals. Cancer Res Treat 36:103–114
Fain O, Hamidou M, Cacoub P, Godeau B, Wechsler B, Paries J, Stirnemann J, Morin AS, Gatfosse M, Hanslik T, Belmatoug N, Bletry O, Cevallos R, Delevaux I, Fisher E, Hayem G, Kaplan G, Le Hello C, Mouthon L, Larroche C, Lemaire V, Piette AM, Piette JC, Ponge T, Puechal X, Rossert J, Sarrot-Reynauld F, Sicard D, Ziza JM, Kahn MF, Guillevin L, Godeau P (2007) Vasculitides associated with malignancies: analysis of sixty patients [Vasculitis and neoplasms. 14 cases]. Arthritis Rheum 57:1473–1480
Ahn JK, Cha HS, Koh EM, Kim SH, Kim YG, Lee CK, Yoo B (2008) Behcet’s disease associated with bone marrow failure in Korean patients: clinical characteristics and the association of intestinal ulceration and trisomy 8. Rheumatology (Oxford) 47:1228–1230
Kawabata H, Sawaki T, Kawanami T, Shimoyama K, Karasawa H, Fukushima T, Masaki Y, Ogawa N, Hirose Y, Ozaki K, Shimanaka K, Takase S, Ueno H, Umehara H (2006) Myelodysplastic syndrome complicated with inflammatory intestinal ulcers: significance of trisomy 8. Int Med 45:1309–1314
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Ahn, J.K., Oh, J.M., Lee, J. et al. Behcet’s disease associated with malignancy in Korea: a single center experience. Rheumatol Int 30, 831–835 (2010). https://doi.org/10.1007/s00296-009-1319-3
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DOI: https://doi.org/10.1007/s00296-009-1319-3