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Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study

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Abstract

Chronic periaortitis is thought to result from an autoallergic reaction to oxidized low-density lipoprotein (OxLDL). No data exist on lipid profile and atherosclerotic biomarkers. We investigated circulating levels of OxLDL and of anti-OxLDL (aOxLDL) antibodies in patients with chronic periaortitis using the cross-sectional case–control study on 20 patients with chronic periaortitis. Patients were compared to 20 age- and sex-matched controls. aOxLDL antibodies were measured by ELISA and expressed as mean optical density values at 450 nm from duplicate measurements (OD450). aOxLDL antibody titers (median [interquartile range]) did not differ significantly between patients and controls (aOxLDL-IgM: 0.70 [0.24–1.08] vs. 0.54 [0.25–0.73] OD450; aOxLDL-IgG: 0.59 [0.38–0.75] vs. 0.41[0.33–0.63]OD450). Female patients had higher aOxLDL-IgM levels than male patients (1.02 [0.46–1.38] vs. 0.29 [0.22–0.84] OD450; P = 0.05). aOxLDL-IgM titers were lower in patients with cardiovascular disease (CVD) than in patients without CVD (0.22 [0.16–0.37] vs. 0.92 [0.70–1.30] OD450; P = 0.003) and correlated positively with HDL-cholesterol (r = 0.47, 95% CI 0.02–0.69; P = 0.03) and inversely with diastolic blood pressure (r = −0.46, 95% CI −0.75 to −0.01; P = 0.03) and OxLDL/apoB ratio (r = −0.41, 95% CI −0.73 to 0.04; P = 0.06). No differences or associations were found between aOxLDL-IgG titers and other variables between or within patients and/or controls. In patients OxLDL levels correlated with smoking pack-years (r = 0.58, 95% CI 0.17–0.81; P = 0.007). Data suggest a differing innate immune response to OxLDL in patients with chronic periaortitis compared to controls. Whether this response is causally related to chronic periaortitis development remains to be clarified.

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References

  1. Mitchinson MJ (1986) Retroperitoneal fibrosis revisited. Arch Pathol Lab Med 110:784–786

    CAS  PubMed  Google Scholar 

  2. Parums DV (1990) The spectrum of chronic periaortitis. Histopathology 16:423–431

    Article  CAS  PubMed  Google Scholar 

  3. Parums DV, Choudhury RP, Shields SA, Davies AH (1991) Characterisation of inflammatory cells associated with ‘idiopathic retroperitoneal fibrosis’. Br J Urol 67:564–568

    Article  CAS  PubMed  Google Scholar 

  4. Parums DV, Chadwick DR, Mitchinson MJ (1986) The localisation of immunoglobulin in chronic periaortitis. Atherosclerosis 61:117–123

    Article  CAS  PubMed  Google Scholar 

  5. Parums DV, Brown DL, Mitchinson MJ (1990) Serum antibodies to oxidized low-density lipoprotein and ceroid in chronic periaortitis. Arch Pathol Lab Med 114:383–387

    CAS  PubMed  Google Scholar 

  6. Bullock N (1988) Idiopathic retroperitoneal fibrosis. BMJ 297:240–241

    Article  CAS  PubMed  Google Scholar 

  7. Baker LRI (2003) Auto-allergic periaortitis (idiopathic retroperitoneal fibrosis). BJU 92:663–665

    Article  CAS  Google Scholar 

  8. Meier P, Vogt B, Blanc E (2007) Rethinking the triggering inflammatory processes of chronic periaortitis. Nephron Exp Nephrol 105:e17–e23

    Article  PubMed  Google Scholar 

  9. Haug ES, Skomsvoll JF, Jacobsen G, Halvorsen TB, Saether OD, Myhre HO (2003) Inflammatory aortic aneurysm is associated with increased incidence of autoimmune disease. J Vasc Surg 38:492–497

    Article  CAS  PubMed  Google Scholar 

  10. Vaglio A, Corradi D, Manenti L, Ferretti S, Garini G, Buzio C (2003) Evidence of autoimmunity in chronic periaortitis: a prospective study. Am J Med 114:454–462

    Article  PubMed  Google Scholar 

  11. Galkina E, Ley K (2009) Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol 27:165–197

    Article  CAS  PubMed  Google Scholar 

  12. Van Bommel EFH, van der Veer SJ, Hendriksz TR, Bleumink GS (2008) Persistent chronic periaortitis (‘inflammatory aneurysm’) after abdominal aortic aneurysm repair: systematic review of the literature. Vasc Med 13:293–303

    Article  PubMed  Google Scholar 

  13. Bommel Van, Hendriksz TR, Huiskes AW, Zeegers AG (2006) Brief communication: tamoxifen therapy for idiopathic retroperitoneal fibrosis. Ann Intern Med 144:101–106

    PubMed  Google Scholar 

  14. Van Bommel EF, Siemes C, Hak LE, van der Veer SJ, Hendriksz TR (2007) Long-term renal and patient outcome in idiopathic retroperitoneal fibrosis treated with prednisone. Am J Kidney Dis 49:615–625

    Article  PubMed  Google Scholar 

  15. van Tits LJH, de Waart F, Hak-Lemmers HLM (2001) Effects of alfa-Tocopherol on superoxide production and plasma intercellular adhesion molecule-1 and antibodies to oxidized LDL in chronic smokers. Free Radical Biol Med 30:1122–1129

    Article  Google Scholar 

  16. Virella G, Lopes-Virella MF (2003) Lipoprotein autoantibodies: measurement and significance. Clin Diagn Lab Immunol 10:499–505

    CAS  PubMed  Google Scholar 

  17. Shoenfeld Y, Wu R, Dearing LD, Matsuura E (2004) Are anti-oxidized low-density lipoprotein antibodies pathogenic or protective? Circulation 110(17):2552–2558

    Article  PubMed  Google Scholar 

  18. Tsimikas S, Willerson JT, Ridker PM (2006) C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 47:C19–C31

    Article  CAS  PubMed  Google Scholar 

  19. Van Bommel EFH, Jansen I, Hendriksz TR, Aarnoudse ALHJ (2009) Idiopathic retroperitoneal fibrosis: prospective evaluation of incidence and clinicoradiological presentation. Medicine 88:193–201

    Article  PubMed  Google Scholar 

  20. Bonanni B, Johansson H, Gandini S et al (2003) Effect of tamoxifen at low doses on ultrasensitive C-reactive protein in healthy women. J Thromb Haemost 1:2149–2152

    Article  CAS  PubMed  Google Scholar 

  21. De Medina P, Payre BL, Bernad J et al (2004) Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells. J Pharmacol 308:1165–1173

    Google Scholar 

  22. Grainger DJ, Schofield PM (2005) Tamoxifen for the prevention of mycardial infarction in humans: preclinical and clinical evidence. Circulation 112:3018–3024

    PubMed  Google Scholar 

  23. Tinahones FJ, Gomez-Zumaquero JM, Garrido-Sanchez L et al (2005) Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population. J Lipid Res 46:452–457

    Article  CAS  PubMed  Google Scholar 

  24. Gomez-Zumaquero JM, Tinahones FJ, de Ramón E, Camps M, Garrido L, Soriguer FJ (2004) Association of biological markers of activity of lupus erythematosus with levels of anti-oxidized low-density lipoprotein antibodies. Rheumatology 43:510–513

    Article  CAS  PubMed  Google Scholar 

  25. Tsutsumi Z, Moriwaki Y, Takahashi S, Ka T, Yamamoto T (2004) Oxidized low-density lipoprotein autoantibodies in patients with primary gout: effect of urate-lowering therapy. Clin Chim Acta 339:117–122

    Article  CAS  PubMed  Google Scholar 

  26. Winyard PG, Tatzber F, Esterbauer H, Kus ML, Blake DR, Morris CJ (1993) Presence of foam cells containing oxidised low density lipoprotein in the synovial membrane from patient with rheumatoid arthritis. Ann Rheum Dis 52:677–680

    Article  CAS  PubMed  Google Scholar 

  27. Dotevall A, Hulthe J, Rosengren A, Wiklund O, Wilhelmsen L (2001) Autoantibodies against oxidized low-density lipoprotein and C-reactive protein are associated with diabetes and myocardial infarction in women. Clin Sci 101:523–531

    Article  CAS  PubMed  Google Scholar 

  28. Georgiades SJ, Wu R, Thulin T, Frostegard J (2006) Antibodies of IgM subclass to phosphorycholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension. Atherosclerosis 188:160–166

    Article  PubMed  Google Scholar 

  29. Orchard TJ, Virella G, Forrest KY, Evans RW, Becker DJ, Lopes-Virella MF (1999) Antibodies to oxidized LDL predict coronary artery disease in type 1 diabetes: a nested case-control study from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 48(7):1454–1458

    Google Scholar 

  30. Van Tits LHJ, Himbergen TM, Lemmers HLM, de Graaf J, Stalenhoef AFH (2006) Proportion of oxidized LDL relative to plasma apolipoprotein B does not change during statin therapy in patients with heterozygous familial hypercholesterolemia. Atherosclerosis 185:307–312

    Article  PubMed  Google Scholar 

  31. Van Tits LHJ, De Graaf J, Hak-Lemmers H, Bredie S, Demacker P, Holvoet P, Stalenhoef AFH (2003) Increased levels of low-density lipoprotein oxidation in patients with familial hypercholesterolemia and in end-stage renal disease patients on hemodialysis. Lab Invest 83:13–21

    PubMed  Google Scholar 

  32. Swets BP, Brouwer DAJ, Cohen Tervaert JW (2001) Patients with systemic vasculitis have increased levels of autoantibodies against oxidized LDL. Clin Exp Immunol 124:163–167

    Article  CAS  PubMed  Google Scholar 

  33. Heikkinen AM, Niskanen L, Ylä-Herttuala S et al (1998) Postmenopausal hormone replacement therapy and autoantibodies against oxidized LDL. Maturitas 29:155–161

    Article  CAS  PubMed  Google Scholar 

  34. Bureau I, Laporte F, Favier M et al (2002) No antioxidant effect of combined HRT on LDL oxidizability and oxidative stress biomarkers in treated post-menopausal women. J Am Coll Nutr 21:333–338

    CAS  PubMed  Google Scholar 

  35. Hoogerbrugge N, Zillekens MC, Jansen H et al (1998) Estrogen replacement decreased the levels of antibodies against oxidized low density lipoprotein in postmenopausal women with coronary heart disease. Metabolism 47:675–680

    Article  CAS  PubMed  Google Scholar 

  36. Uint L, Gebara OCE, Pinto LB et al (2003) Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein. Braz J Med Biol Res 36:491–494

    Article  CAS  PubMed  Google Scholar 

  37. Meisinger C, Baumert J, Khuseyinova N, Loewel H, Koenig W (2005) Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population. Circulation 112:651–657

    Article  CAS  PubMed  Google Scholar 

  38. Hulthe J, Fagerberg B (2002) Circulating oxidized LDL is associated with subclinical atherosclerosis development and inflammatory cytokines (AIR study). Arterioscler Thromb Vasc Biol 22:1162–1167

    Article  CAS  PubMed  Google Scholar 

  39. Nitecki SS, Hallett JW, Stanson AW, Ilstrup DM, Bower TC, Cherry KJ, Gloviczki P, Pairolero PC (1996) Inflammatory abdominal aneurysms: a case-control study. J Vasc Surg 23:860–869

    Article  CAS  PubMed  Google Scholar 

  40. Frostegard J, Ruihua WU, Lemne C, Thulin T, Witzum JL, de Faires U (2003) Circulating oxidized low-density lipoprotein is increased in hypertension. Clin Sci 105:615–620

    Article  CAS  PubMed  Google Scholar 

  41. Bergmark C, Wu R, de Faire U, Lefvert AK, Swedenborg J (1995) Patients with early-onset peripheral vascular disease have increased levels of autoantibodies against oxidized LDL. Arterioscler Thromb Vasc Biol 15:441–445

    CAS  PubMed  Google Scholar 

  42. Martorana D, Vaglio A, Greco P, Zanetti A, Moroni G, Salvarani C, Savi M, Buzio C, Neri TM (2006) Chronic periaortitis and HLA-DRB1*03: another clue to an autoimmune origin. Arthritis Rheum 55:126–130

    Article  CAS  PubMed  Google Scholar 

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Acknowledgment

We thank Heidi Lemmers for technical assistance.

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Authors and Affiliations

  1. Department of Internal Medicine, Albert Schweitzer Hospital, P.O. Box 444, 3300 AK, Dordrecht, The Netherlands

    E. F. H. van Bommel & E. A. van den Berg

  2. Department of Clinical Chemistry, Albert Schweitzer Hospital, Dordrecht, The Netherlands

    J. Prins

  3. Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    L. J. H. van Tits & A. F. H. Stalenhoef

Authors
  1. E. F. H. van Bommel
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  2. L. J. H. van Tits
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  3. E. A. van den Berg
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  5. A. F. H. Stalenhoef
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Correspondence to E. F. H. van Bommel.

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van Bommel, E.F.H., van Tits, L.J.H., van den Berg, E.A. et al. Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study. Rheumatol Int 31, 201–208 (2011). https://doi.org/10.1007/s00296-009-1288-6

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  • DOI: https://doi.org/10.1007/s00296-009-1288-6

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