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Hyperuricemia and its related factors in an urban population, Izmir, Turkey

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Abstract

The aim of this study was to examine the prevalence of hyperuricemia and its associated factors in an urban area of Izmir, located in western Turkey. Our study group was selected by computerized sampling from the participants of a larger population-based study searching for the prevalence of rheumatoid arthritis in Balcova and Narlidere districts of Izmir. A total of 132 subjects (69 women and 63 men) were included in this study. Serum uric acid, glucose, creatinine and lipid levels were studied. Body composition along with body fat percentage was determined anthropometrically. A total of 16 subjects had hyperuricemia (4 women and 12 men). The overall prevalence of hyperuricemia was 12.1% and the mean uric acid level was 4.9 ± 1.3 mg/dl. Males had significantly higher uric acid levels than females (P < 0.05; 5.5 ± 1.3 vs. 4.3 ± 1.1 mg/dl, respectively). The prevalence of hypertension, diabetes, obesity and metabolic syndrome was 24.4, 5.3, 28 and 26.5%, respectively. There was no gouty subject. Sum of skinfold thickness (SFT) measurements and creatinine levels were the independent predictors of hyperuricemia (β = 0.45, 0.47, respectively). Uric acid measurement is important not only for inflammatory rheumatic disorders but also for predicting metabolic syndrome and related coronary artery disease. There is sex difference in uric acid levels in favor of women most probably explained by gonadal hormones. Hyperuricemia is significantly predicted by anthropometric measure of SFT which is a simple clinical screening method along with creatinine levels.

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References

  1. Ghei M, Mihailescu M, Levinson D (2002) Pathogenesis of hyperuricemia: recent advances. Curr Rheumatol Rep 4:270–274. doi:10.1007/s11926-002-0076-z

    Article  PubMed  Google Scholar 

  2. Alderman MH (2001) Serum uric acid as a cardiovascular risk factor for heart disease. Curr Hypertens Rep 3:184–189. doi:10.1007/s11906-001-0036-4

    Article  PubMed  CAS  Google Scholar 

  3. Akar S, Birlik M, Gurler O, Sari I, Onen F, Manisali M, Tirpan K, Demir T, Meral M, Akkoc N (2004) The prevalence of rheumatoid arthritis in an urban population of Izmir-Turkey. Clin Exp Rheumatol 22:416–420

    PubMed  CAS  Google Scholar 

  4. Durnin JV, Womersley J (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32:77–97. doi:10.1079/BJN19740060

    Article  PubMed  CAS  Google Scholar 

  5. Siri NE (1956) Advances in biological and medical physics. Academic Press, London

    Google Scholar 

  6. Wallace SL, Robinson H, Masi AT, Decker JL, McCarty DJ, Yu TF (1977) Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum 20:895–900. doi:10.1002/art.1780200320

    Article  PubMed  CAS  Google Scholar 

  7. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) (2001) JAMA 285:2486–2497. doi:10.1001/jama.285.19.2486

  8. Vazquez-Mellado J, Alvarez Hernandez E, Burgos-Vargas R (2004) Primary prevention in rheumatology: the importance of hyperuricemia. Best Pract Res Clin Rheumatol 18:111–124. doi:10.1016/j.berh.2004.01.001

    Article  PubMed  CAS  Google Scholar 

  9. Zaka R, Williams CJ (2006) New developments in the epidemiology and genetics of gout. Curr Rheumatol Rep 8:215–223. doi:10.1007/s11926-996-0028-0

    Article  PubMed  CAS  Google Scholar 

  10. Wannamethee SG (2001) Serum uric acid is not an independent risk factor for coronary heart disease. Curr Hypertens Rep 3:190–196. doi:10.1007/s11906-001-0037-3

    Article  PubMed  CAS  Google Scholar 

  11. Sanisoglu SY, Oktenli C, Hasimi A, Yokusoglu M, Ugurlu M (2006) Prevalence of metabolic syndrome-related disorders in a large adult population in Turkey. BMC Public Health 6:92. doi:10.1186/1471-2458-6-92

    Article  PubMed  Google Scholar 

  12. Onat A, Ceyhan K, Erer B, Basar O, Uysal O, Sansoy V (2003) Systolic, diastolic, and pulse pressures as coronary risk factors in a population with low cholesterol levels: a prospective 10-year evaluation. Clin Cardiol 26:91–97. doi:10.1002/clc.4960260209

    Article  PubMed  Google Scholar 

  13. Facchini F, Chen YD, Hollenbeck CB, Reaven GM (1991) Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 266:3008–3011. doi:10.1001/jama.266.21.3008

    Article  PubMed  CAS  Google Scholar 

  14. Rathmann W, Funkhouser E, Dyer AR, Roseman JM (1998) Relations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study coronary artery risk development in young adults. Ann Epidemiol 8:250–261. doi:10.1016/S1047-2797(97)00204-4

    Article  PubMed  CAS  Google Scholar 

  15. Nakanishi N, Yoshida H, Nakamura K, Suzuki K, Tatara K (2001) Predictors for development of hyperuricemia: an 8-year longitudinal study in middle-aged Japanese men. Metabolism 50:621–626. doi:10.1053/meta.2001.24196

    Article  PubMed  CAS  Google Scholar 

  16. Onat A, Uyarel H, Hergenc G, Karabulut A, Albayrak S, Sari I, Yazici M, Keles I (2006) Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens 19:1055–1062. doi:10.1016/j.amjhyper.2006.02.014

    Article  PubMed  CAS  Google Scholar 

  17. Yumuk VD, Hatemi H, Tarakci T, Uyar N, Turan N, Bagriacik N, Ipbuker A (2005) High prevalence of obesity and diabetes mellitus in Konya, a central Anatolian city in Turkey. Diabetes Res Clin Pract 70:151–158. doi:10.1016/j.diabres.2005.03.030

    Article  PubMed  Google Scholar 

  18. Soysal A, Demiral Y, Soysal D, Ucku R, Koseoglu M, Aksakoglu G (2005) The prevalence of metabolic syndrome among young adults in Izmir, Turkey. Anadolu Kardiyol Derg 5:196–201

    PubMed  Google Scholar 

  19. Luk AJ, Simkin PA (2005) Epidemiology of hyperuricemia and gout. Am J Manag Care 11:S435–S442. quiz S465–438

    PubMed  Google Scholar 

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Sari, I., Akar, S., Pakoz, B. et al. Hyperuricemia and its related factors in an urban population, Izmir, Turkey. Rheumatol Int 29, 869–874 (2009). https://doi.org/10.1007/s00296-008-0806-2

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  • DOI: https://doi.org/10.1007/s00296-008-0806-2

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