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Clinical features of Thai male lupus: an age-matched controlled study

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Abstract

To study the prevalence, and clinical and laboratory manifestations of male lupus, and compare these findings with their age-matched female lupus in Thai patients. The medical records of patients with diagnosed Systemic lupus erythematosus (SLE) were reviewed. The clinical and laboratory manifestations were determined. There were 37 males in 508 patients with SLE (7.3%). There was no difference in mean ± SD age and disease duration between male patients and their 74 female age-matched controls. When compared with females, male lupus patients had a significantly lower prevalence of alopecia (13.6 vs. 44.6%, P = 0.001), arthralgia (2.7 vs. 17.6%, P = 0.032), Raynaud’s phenomenon (0.0 vs. 12.2%, P = 0.027), and psychosis (0.0 vs. 13.5%, P = 0.029), but they had a significantly higher prevalence of thrombocytopenia (32.4 vs. 12.2%, P = 0.019) and renal insufficiency (40.5 vs. 16.4%, P = 0.006). Our study showed several existing sex-related differences in the clinical manifestations in Thai SLE patients.

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References

  1. Lahita RG (1999) The role of sex hormones in systemic lupus erythematosus. Curr Opin Rheumatol 11(5):352–356

    Article  PubMed  CAS  Google Scholar 

  2. Lopez P, Mozo L, Gutierrez C, Suarez A (2003) Epidemiology of systemic lupus erythematosus in a northern Spanish population: gender and age influence on immunological features. Lupus 12(11):860–865

    Article  PubMed  CAS  Google Scholar 

  3. Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Parks CG, Gilkeson GS (1998) Hormonal, environmental, and infectious risk factors for developing systemic lupus erythematosus. Arthritis Rheum 41(10):1714–1724

    Article  PubMed  CAS  Google Scholar 

  4. Cooper GS, Parks CG, Treadwell EL, St Clair EW, Gilkeson GS, Cohen PL, et al (2002) Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States. Lupus 11(3):161–167

    Article  PubMed  CAS  Google Scholar 

  5. Miller MH, Urowitz MB, Gladman DD, Killinger DW (1983) Systemic lupus erythematosus in males. Medicine (Baltimore) 62(5):327–334

    Article  CAS  Google Scholar 

  6. Kaufman LD, Gomez-Reino JJ, Heinicke MH, Gorevic PD (1989) Male lupus: retrospective analysis of the clinical and laboratory features of 52 patients, with a review of the literature. Semin Arthritis Rheum 18(3):189–197

    Article  PubMed  CAS  Google Scholar 

  7. Ward MM, Studenski S (1990) Systemic lupus erythematosus in men: a multivariate analysis of gender differences in clinical manifestations. J Rheumatol 17(2):220–224

    PubMed  CAS  Google Scholar 

  8. Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P, et al. (1993) Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. The European Working Party on systemic lupus erythematosus. Medicine (Baltimore) 72(2):113–124

    CAS  Google Scholar 

  9. Koh WH, Fong KY, Boey ML, Feng PH (1994) Systemic lupus erythematosus in 61 Oriental males. A study of clinical and laboratory manifestations. Br J Rheumatol 33(4):339–342

    Article  PubMed  CAS  Google Scholar 

  10. Molina JF, Drenkard C, Molina J, Cardiel MH, Uribe O, Anaya JM, et al (1996) Systemic lupus erythematosus in males. A study of 107 Latin American patients. Medicine (Baltimore) 75(3):124–130

    Article  CAS  Google Scholar 

  11. Mok CC, Lau CS, Chan TM, Wong RW (1999) Clinical characteristics and outcome of southern Chinese males with systemic lupus erythematosus. Lupus 8(3):188–196

    Article  PubMed  CAS  Google Scholar 

  12. Voulgari PV, Katsimbri P, Alamanos Y, Drosos AA (2002) Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literature. Lupus 11(11):722–729

    Article  PubMed  CAS  Google Scholar 

  13. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25(11):1271–1277

    Article  PubMed  CAS  Google Scholar 

  14. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725

    Article  PubMed  CAS  Google Scholar 

  15. Deesomchok U, Tumrasvin T (1992) Clinical features of systemic lupus erythematosus in Thai males and females. J Med Assoc Thai 75(3):133–140

    PubMed  CAS  Google Scholar 

  16. Hochberg MC, Boyd RE, Ahearn JM, Arnett FC, Bias WB, Provost TT, et al (1985) Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets. Medicine (Baltimore) 64(5):285–295

    CAS  Google Scholar 

  17. Specker C, Becker A, Lakomek HJ, Bach D, Grabensee B (1994) Systemic lupus erythematosus in men-a different prognosis?. Z Rheumatol 53(6):339–345

    PubMed  CAS  Google Scholar 

  18. Garcia MA, Marcos JC, Marcos AI, Pons-Estel BA, Wojdyla D, Arturi A, et al (2005) Male systemic lupus erythematosus in a Latin-American inception cohort of 1214 patients. Lupus 14(12):938–946

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Worawit Louthrenoo.

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Mongkoltanatus, J., Wangkaew, S., Kasitanon, N. et al. Clinical features of Thai male lupus: an age-matched controlled study. Rheumatol Int 28, 339–344 (2008). https://doi.org/10.1007/s00296-007-0442-2

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  • DOI: https://doi.org/10.1007/s00296-007-0442-2

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