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Role of amyloidosis in determining the prognosis of dialyzed patients with rheumatoid arthritis

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Abstract

The role of secondary amyloidosis in determining the prognosis of dialyzed patients with rheumatoid arthritis (RA) was examined in 22 patients with a mean age of 60.1 years included 21 renal amyloidosis. RA duration until the start of dialysis was 19.5 ± 7.2 years and the observation period after introduction 27.1 ± 26.4 months. Of the 14 dead cases, four died due to sepsis, three due to gastrointestinal tract bleeding, two due to congestive heart failure, and eight cases died within 5 months after starting dialysis. When comparing the eight survivors and the nine non-survivors who died within 2 years after the start of dialysis, the former patients showed significantly higher serum albumin, and lower electrocardiogram score and cardiothoracic ratios at the time of introduction to dialysis. The careful prevention and treatment of infection, cerebrovascular and/or gastrointestinal tract complications seem to be necessary to improve the prognosis of RA patients after the initiation of renal replacement therapy.

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Acknowledgments

We thank Mr. B. Quinn for carefully reading and editing the manuscript.

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Authors and Affiliations

  1. The Division of Nephrology and Rheumatology, Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan

    Toru Sanai, Fumio Nanishi, Masatoshi Nagata, Tadashi Hirano & Eiichi Suematsu

  2. The Department of Orthopedics, Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan

    Yukio Esaki & Hisaaki Miyahara

  3. The Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Mitsuo Iida

  4. Abe Clinic, 2-3-8 Taharashinmachi, Kokuraminami-ku, Kitakyushu-city, 800-0226, Fukuoka, Japan

    Toru Sanai

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  1. Toru Sanai
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  2. Fumio Nanishi
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  3. Masatoshi Nagata
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  4. Tadashi Hirano
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  5. Eiichi Suematsu
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  6. Yukio Esaki
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  7. Hisaaki Miyahara
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  8. Mitsuo Iida
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Correspondence to Toru Sanai.

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Sanai, T., Nanishi, F., Nagata, M. et al. Role of amyloidosis in determining the prognosis of dialyzed patients with rheumatoid arthritis. Rheumatol Int 27, 363–367 (2007). https://doi.org/10.1007/s00296-006-0225-1

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  • DOI: https://doi.org/10.1007/s00296-006-0225-1

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