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Decreased protein S activity is related to the disease activity of Behcet’s disease

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Abstract

We wanted to see whether the active inflammation in Behcet’s disease (BD) can cause a thrombotic disorder by decreasing the protein S (PS) activity, and we evaluated the relationship between the decreased PS activity and the disease activity of BD. We included 122 patients with BD whose PS activity levels were measured. In 51 patients, the PS activity was measured again when there were changes in the number of items of “The Behcet’s Disease Current Activity Form (BDCAF)”. The thrombosis rate was 2.5% (3/122), and the PS activity was low in all three of the patients with thrombosis. The incidence of low PS activity in the total 122 BD patients was 27% (33/122). The incidence of the low PS activity in the active BD patients was 33.7% (31/92), and this was significantly more frequent than in the inactive BD patients, (6.7%, 2/30) (χ2-test, P value = 0.0038). The decrease of PS activity had good correlation with the increase of the number of BDCAF items (r = −0.351, P value = 0.012). The PS activity decrease is related to the BD activity. The low PS activity can be the risk factor for thrombotic disorder and also the activity marker for BD and other inflammatory diseases.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, College of Medicine, Inha University, 3rd Street Shinheung-dong, Jung-gu, Inchon, 400-711, South Korea

    Seong Ryul Kwon, Mie Jin Lim & Won Park

  2. Department of Occupational and Environmental Medicine, College of Medicine, Inha University Hospital, Inchon, South Korea

    Shin Goo Park

  3. Department of Laboratory Medicine, College of Medicine, Inha University Hospital, Inchon, South Korea

    Yeon Sook Moon

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  1. Seong Ryul Kwon
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  2. Mie Jin Lim
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  3. Shin Goo Park
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  4. Yeon Sook Moon
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  5. Won Park
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Correspondence to Won Park.

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This work was supported by Inha University Research Grant.

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Kwon, S.R., Lim, M.J., Park, S.G. et al. Decreased protein S activity is related to the disease activity of Behcet’s disease. Rheumatol Int 27, 39–43 (2006). https://doi.org/10.1007/s00296-006-0214-4

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  • DOI: https://doi.org/10.1007/s00296-006-0214-4

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