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Therapy with infliximab decreases the CD4+CD28− T cell compartment in peripheral blood in patients with rheumatoid arthritis

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Abstract

Chronic inflammatory syndromes such as rheumatoid arthritis (RA) are associated with high frequencies of CD4+CD28− T cells. The number of these cells is genetically determined and may also be a consequence of chronic exposure to tumor necrosis factor-alpha (TNFα). The aim of this study was to examine whether the reported efficacy of anti-TNFα therapy in RA involves a resurgence of T cell populations that re-express CD28. After 36-week therapy with infliximab, a significant decrease in CD4+CD28− T cells in RA patients was observed in comparison with baseline. The results suggest that TNFα-neutralizing therapy may restore T cell homeostasis and reduce expansion of the CD28− T cells, which are cytotoxic and may contribute to organ manifestations in RA.

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Authors and Affiliations

  1. Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70–111, Szczecin, ul. Powst. Wlkp. 72, Poland

    Andrzej Pawlik & Barbara Gawronska Szklarz

  2. Department of Rheumatology, Pomeranian Medical University, Szczecin, Poland

    Lidia Ostanek, Iwona Brzosko & Marek Brzosko

  3. Department of Pathology, Pomeranian Medical University, Szczecin, Poland

    Marek Masiuk & Boguslaw Machalinski

Authors
  1. Andrzej Pawlik
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  2. Lidia Ostanek
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  3. Iwona Brzosko
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  4. Marek Brzosko
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  5. Marek Masiuk
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  6. Boguslaw Machalinski
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  7. Barbara Gawronska Szklarz
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Correspondence to Andrzej Pawlik.

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Pawlik, A., Ostanek, L., Brzosko, I. et al. Therapy with infliximab decreases the CD4+CD28− T cell compartment in peripheral blood in patients with rheumatoid arthritis. Rheumatol Int 24, 351–354 (2004). https://doi.org/10.1007/s00296-003-0374-4

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  • DOI: https://doi.org/10.1007/s00296-003-0374-4

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