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Human leukocyte antigen distribution in Israeli patients with psoriatic arthritis

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Abstract

Objectives

This study was designed to investigate the distribution of human leukocyte antigen (HLA) classes I and II in a group of Israeli Jewish patients with psoriatic arthritis (PsA) and identify HLA markers related to disease manifestation in PsA.

Patients and methods

Human leukocyte antigens class I and class II (both serologically and from oligotyping) were tested in a group of 50 consecutive patients with PsA, 32 with skin psoriasis (PSO), and 255 healthy persons. Data on age, gender, disease duration, and pattern of rheumatological manifestations—oligoarthritis, polyarthritis, spinal involvement, involvement of distal interphalangeal joints (DIPs), and enthesitis—were registered.

Results

Human leukocyte antigens A3, B13, and B38 alleles were found to be significantly prevalent in PsA compared with PSO patients and healthy controls. HLA-B27 was found in only two out of 50 patients with PsA. Patients with PSO and PsA had significantly increased incidence of HLA-DRB0101 and -DRB0301, while the frequency of HLA-DRB0403 was significantly higher among patients with PsA of Ashkenazi origin. We found a statistically significant association between DIP involvement and the presence of HLA-A26 and -B38, while HLA-DRB0301 was related to spinal involvement.

Conclusions

Psoriatic arthritis in Israeli patients seems to be associated with the presence of HLA-A3, -B13, -B38, -DRB0101, and -DRB0301. HLA-B27 was not a marker of PsA in this cohort of patients, including patients with psoriatic spondyloarthropathy.

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Authors and Affiliations

  1. Department of Rheumatology, Sourasky Medical Center, Tel Aviv, Israel

    Ori Elkayam & Dan Caspi

  2. Shmuel Harofeh Geriatric Medical Center, Beer-Yaakov, Israel

    Refael Segal

  3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Ori Elkayam, Refael Segal & Dan Caspi

  4. Department of Rheumatology, Tel Aviv Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel

    Ori Elkayam

Authors
  1. Ori Elkayam
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  2. Refael Segal
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  3. Dan Caspi
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Correspondence to Ori Elkayam.

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Elkayam, O., Segal, R. & Caspi, D. Human leukocyte antigen distribution in Israeli patients with psoriatic arthritis. Rheumatol Int 24, 93–97 (2004). https://doi.org/10.1007/s00296-003-0325-0

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  • DOI: https://doi.org/10.1007/s00296-003-0325-0

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