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The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos)

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Abstract

Osteoporotic fractures can be a major cause of morbidity. It is important to determine the impact of fractures on health-related quality of life (HRQL). A total of 3,394 women and 1,122 men 50 years of age and older, who were recruited for the Canadian Multicentre Osteoporosis Study (CaMos), participated in this cross-sectional study. Minimal trauma fractures of the hip, pelvis, spine, lower body (included upper and lower leg, knee, ankle, and foot), upper body (included arm, elbow, sternum, shoulder, and clavicle), wrist and hand (included forearm, hand, and finger), and ribs were studied. Participants with subclinical vertebral deformities were also examined. The Health Utilities Index Mark II and III Systems were used to assess HRQL. Past osteoporotic fractures varied in prevalence from 1.2% (pelvis) to 27.8% (lower body) in women and 0.3% (pelvis) to 29.3% (wrist) in men. Multivariate linear regression analyses [parameter estimates and corresponding 95% confidence intervals (CI)] indicated that minimal trauma fractures were negatively associated with HRQL and that this relationship depends on fracture type and gender. The multi-attribute scores for the Mark II system were negatively related to hip (−0.05; 95% CI: −0.09, −0.01), lower body (−0.02; 95% CI: −0.03, −0.000), and subclinical vertebral fractures (−0.02; 95% CI: −0.03, −0.00) for women. The multi-attribute scores for the Mark III system were negatively related to hip (−0.09; 95% CI: −0.14, −0.03) and rib fractures (−0.06; 95% CI: −0.11, −0.00) for women, and rib fractures (−0.06; 95% CI: −0.12, −0.00) for men. In conclusion, this study demonstrates a negative association between osteoporotic fractures and quality of life in both women and men.

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Acknowledgements

The authors would like to thank the rest of the CaMoS Research Group, including: J Allan, L. Blondeau, B. Gardner-Bray, P. Hartman, J. Thingvold, S. Kirkland, N. Kreiger, P. Krutzen, S. Godmaire, E. Lejeune, B.C. Lentle, B. Matthews, N.Migneault-Roy, M. Parsons, R.S. Rittmaster, L. Robertson, B. Stanfield, and Y. Vigna.

L. Joseph is a senior scientist funded by CIHR. The CaMos was funded by the Senior's Independence Research Program through the National Health Research and Development Program of Health Canada (Project No. 6605-4003-OS). The Medical Research Council of Canada, MRC-PMAC Health Program, Merck Frosst Canada Inc., Eli Lilly Canada Inc., Procter and Gamble Pharmaceuticals Canada Inc., and the Dairy Farmers of Canada.

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Authors and Affiliations

  1. Department of Medicine, St. Joseph's Hospital, McMaster University, Charlton Avenue East, Suite 501, Hamilton, Ontario, L8 N 1Y2, Canada

    J. D. Adachi, G. Ioannidis, L. Pickard & A. Papaioannou

  2. CaMos Analysis Centre, McGill University, Montreal, Quebec, Canada

    C. Berger

  3. Department of Medicine/Endocrinology, University of British Columbia, Vancouver, British Columbia, Canada

    J. C. Prior

  4. Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada

    L. Joseph

  5. Department of Medicine, University of Calgary, Calgary, Alberta, Canada

    D. A. Hanley

  6. Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    W. P. Olszynski

  7. Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada

    T. M. Murray

  8. MacKenzie Health Services Research Group, Queen's University, Kingston, Ontario, Canada

    T. Anastassiades & W. Hopman

  9. Department of Medicine, Laval University, Ste-Foy, Quebec, Canada

    J. P. Brown

  10. Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada

    S. Kirkland

  11. Department of Medicine, Memorial University, St. John's, Newfoundland, Canada

    C. Joyce

  12. CaMos National Coordinating Centre, McGill University, Montreal, Quebec, Canada

    S. Poliquin & A. Tenenhouse

  13. Eli Lilly and Company, Toronto, Ontario, Canada

    E. A. Papadimitropoulos

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  1. J. D. Adachi
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  2. G. Ioannidis
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  3. L. Pickard
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  4. C. Berger
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  5. J. C. Prior
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  6. L. Joseph
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  7. D. A. Hanley
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  8. W. P. Olszynski
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  9. T. M. Murray
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  10. T. Anastassiades
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  11. W. Hopman
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  12. J. P. Brown
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  13. S. Kirkland
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  14. C. Joyce
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  15. A. Papaioannou
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  16. S. Poliquin
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  17. A. Tenenhouse
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  18. E. A. Papadimitropoulos
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Corresponding author

Correspondence to J. D. Adachi.

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This study was conducted in conjunction with other members of the CaMOS Research Group.

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Adachi, J.D., Ioannidis, G., Pickard, L. et al. The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int 14, 895–904 (2003). https://doi.org/10.1007/s00198-003-1483-3

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  • DOI: https://doi.org/10.1007/s00198-003-1483-3

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