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Comparison of four different intra-articular injection sites in the knee: a cadaver study

  • Knee
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Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Although intra-articular knee injection is not a complicated procedure, it could be difficult to assess whether the tip of the needle lies free in the joint or is embedded in synovium or other intra-articular soft tissues. The purpose of this study was to evaluate the accuracy rate of intra-articular injection using anteromedial (AM), anterolateral (AL), lateral midpatellar (LMP), and medial midpatellar (MMP) portals in cadavers. In this study 156 knees of 78 fresh cadavers were included. Anterolateral and AM injection to both knees of 39 cadavers (78 knees) were performed. MMP and LMP injection to both knees of other 39 cadavers were also performed. Accuracy rate was the highest (85%) in the AL injection portal and lowest in the MMP portal (56%). In conclusion, the accuracy obtained with use of the MMP portal was significantly lower than that obtained with the use of either the AM (P < 0.05), AL (P < 0.0001), or LMP (P < 0.05) portal. Although AL injection site resulted in good intra-articular delivery with 85% accuracy rate and with a lower incidence of soft tissue infiltration, the results were not statistically significant when compared to AM and LMP portals. Therefore, any of these three portals might be preferred depending on the experience of the physician. On the other hand, 100% accuracy could not be obtained through any portals in the study, which should be kept in mind when treating knee problems with intra-articular medications.

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References

  1. Jackson DW, Simon TM, Aberman HM (2001) Symptomatic articular cartilage degeneration: the impact in the new millennium. Clin Orthop 391(Suppl.):S14–S25

    PubMed  Google Scholar 

  2. Balazs EA (1982) The physical properties of synovial fluid and the special role of hyaluronic acid. In: Helfet AJ (eds) Disorders of the knee, 2nd edn. Lippincott, Philadelphia, pp 61–74

    Google Scholar 

  3. Balazs EA, Denlinger JL (1993) Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol Suppl 39:3–9

    PubMed  CAS  Google Scholar 

  4. Smith MM, Ghosh P (1987) The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment. Rheumatol Int 7:113–122

    Article  PubMed  Google Scholar 

  5. Altman RD, Moskowitz R (1998) Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol 25:2203–2212

    PubMed  CAS  Google Scholar 

  6. Pelletier JP, Martel-Pelletier J (1993) The pathophysiology of osteoarthritis and the implication of the use of hyaluronan and hylan as therapeutic agents in viscosupplementation. J Rheumatol Suppl 39:19–24

    PubMed  CAS  Google Scholar 

  7. Tobetto K, Yasui T, Ando T, Hayaishi M, Motohashi N, Shinogi M, Mori I (1992) Inhibitory effects of hyaluronan on [14C]arachidonic acid release from labeled human synovial fibroblasts. Jpn J Pharmacol 60:79–84

    PubMed  CAS  Google Scholar 

  8. Forrester JV, Balazs EA (1980) Inhibition of phagocytosis by high molecular weight hyaluronate. Immunology 40:435–446

    PubMed  CAS  Google Scholar 

  9. Presti D, Scott JE (1994) Hyaluronan-mediated protective effect against cell damage caused by enzymatically produced hydroxyl (OH.) radicals is dependent on hyaluronan molecular mass. Cell Biochem Funct 12:281–288

    Article  PubMed  CAS  Google Scholar 

  10. Ghosh P (1994) The role of hyaluronic acid (hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluid. Clin Exp Rheumatol 12:75–82

    PubMed  CAS  Google Scholar 

  11. Pozo MA, Balazs EA, Belmonte C (1997) Reduction of sensory responses to passive movements of inflamed knee joints by hylan, a hyaluronan derivative. Exp Brain Res 116:3–9

    Article  PubMed  CAS  Google Scholar 

  12. Jackson DW, Evans NA, Thomas BM (2002) Accuracy of needle placement into the intra-articular space of the knee. J Bone Joint Surg Am 84-A(9):1522–1527

    PubMed  Google Scholar 

  13. Adams ME (1993) An analysis of clinical studies of the use of crosslinked hyaluronan, hylan, in the treatment of osteoarthritis. J Rheumatol Suppl 39:16–18

    PubMed  CAS  Google Scholar 

  14. Adams ME, Atkinson MH, Lussier AJ, Schulz JI, Siminovitch KA, Wade JP, Zummer M (1995) The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal antiinflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthr Cartil 3:213–225

    Article  PubMed  CAS  Google Scholar 

  15. Wobig M, Dickhut A, Maier R, Velter G (1998) Viscosupplementation with hyalan G-F 20: a 26-week controlled trial of efficacy and safety in the osteoarthritic knee. Clin Ther 20:410–423

    Article  PubMed  CAS  Google Scholar 

  16. Scale D, Wobig M, Wolpert W (1994) Viscosupplementation of osteoarthritic knees with hyalan: a treatment schedule study. Curr Ther Res 55:220–232

    Article  Google Scholar 

  17. Lussier A, Cividino AA, McFarlane CA, Olszynski WP, Potashner WJ, De Medicis R (1996) Viscosupplementation with hylan for the treatment of osteoarthritis: findings from clinical practice in Canada. J Rheumatol 23:1579–1585

    PubMed  CAS  Google Scholar 

  18. Jones A, Regan M, Ledingham J, Pattrick M, Manhire A, Doherty M (1993) Importance of placement of intra-articular steroid injections. BMJ 307:1329–1330

    Article  PubMed  CAS  Google Scholar 

  19. Bliddal H (1999) Placement of intra-articular injections verified by mini-air arthrography. Ann Rheum Dis 58:641–643

    Article  PubMed  CAS  Google Scholar 

  20. Wind WM, Smolinski RJ (2004) Reliability of common knee injection sites with low-volume injections. J Arthroplasty 19(7):858–861

    Article  PubMed  Google Scholar 

  21. Waddell D, Estey D, Bricker DC, Marsala A (2001) Viscosupplementation under fluoroscopic control. Am J Med Sports 3:237–241

    Google Scholar 

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Correspondence to Cem Esenyel.

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Esenyel, C., Demirhan, M., Esenyel, M. et al. Comparison of four different intra-articular injection sites in the knee: a cadaver study. Knee Surg Sports Traumatol Arthrosc 15, 573–577 (2007). https://doi.org/10.1007/s00167-006-0231-6

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  • DOI: https://doi.org/10.1007/s00167-006-0231-6

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