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A selective method for determining MRP8 and MRP14 homocomplexes and heterocomplexes by sandwich ELISA for the discrimination of active and non-active osteoarthritis from rheumatoid arthritis in sera and synovial fluids

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Abstract

A new method is described to selectively determine the quantity of monomers and/or homopolymers of MRP8 and MRP14 and heteromers formed by two Ca2+-binding proteins of the S100 protein family. This detection system allows the discrimination of the type and phase of inflammatory processes in the synovial fluids and sera of patients with non-activated osteoarthritis (OAO) and activated osteoarthritis (OA) compared with patients with rheumatoid arthritis (RA).

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Authors and Affiliations

  1. BMA Biomedicals Ltd, Rheinstrasse 28-32, CH-4302, Augst

    G. Burmeister

  2. Schmerzklinik Kirschgarten, Hirschgässlein 13, CH-4051, Basel, Switzerland

    G. Gallacchi

Authors
  1. G. Burmeister
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  2. G. Gallacchi
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Burmeister, G., Gallacchi, G. A selective method for determining MRP8 and MRP14 homocomplexes and heterocomplexes by sandwich ELISA for the discrimination of active and non-active osteoarthritis from rheumatoid arthritis in sera and synovial fluids. Inflammopharmacology 3, 221–230 (1995). https://doi.org/10.1007/BF02659119

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  • DOI: https://doi.org/10.1007/BF02659119

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