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Interleukin-8 (IL-8) in synovial fluid of rheumatoid and nonrheumatoid joint effusions

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Summary

IL-8 was measured in knee joint synovial fluid of 60 patients with rheumatoid arthritis, 8 with gout, 6 with osteoarthritis and 4 with meniscus lesions. IL-8 could be demonstrated in most SF samples. The highest levels were observed in rheumatoid joint effusions, yet mean levels were not significantly different between the different subgroups (mean±SE; RA 1537±3049 pg/ml, gout 570±952 pg/ml, OA/ML 178±188 pg/ml). In RA patients, IL-8 levels could not be related to various serological, clinical or radiological parameters. However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, β2-microglobulin and glucose. These observations suggest that next to the laboratory parameters IL-8 will be a parameter of the activity of the local inflammatory process. The results also demonstrate that IL-8 is not a disease-specific marker of joint inflammation.

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Authors and Affiliations

  1. Department of Internal Medicine, Zuiderziekenhuis, Rotterdam

    C. A. Verburgh

  2. Department of Autoimmune Diseases, Central Laboratory of the Red Cross Blood Transfusion Service, Amsterdam

    M. H. L. Hart & L. A. Aarden

  3. Dept of Rheumatology, The Dr Daniel den Hoed Clinic, Groene Hilledijk 301, NL-3075 EA, Rotterdam, The Netherlands

    A. J. G. Swaak

Authors
  1. C. A. Verburgh
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  2. M. H. L. Hart
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  3. L. A. Aarden
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  4. A. J. G. Swaak
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Verburgh, C.A., Hart, M.H.L., Aarden, L.A. et al. Interleukin-8 (IL-8) in synovial fluid of rheumatoid and nonrheumatoid joint effusions. Clin Rheumatol 12, 494–499 (1993). https://doi.org/10.1007/BF02231778

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  • DOI: https://doi.org/10.1007/BF02231778

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