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Creatine and Creatine Kinase in Health and Disease – A Bright Future Ahead?

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Book cover Creatine and Creatine Kinase in Health and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 46))

Abstract

Many links are reported or suspected between the functioning of creatine, phosphocreatine, the creatine kinase isoenzymes or the creatine biosynthesis enzymes on one hand, and health or disease on the other hand. The aim of the present book was to outline our current understanding on many of these links. In this chapter, we summarize the main messages and conclusions presented in this book. In addition, we refer to a number of recent publications that highlight the pleiotropy in physiological functions of creatine and creatine kinase, and which suggest that numerous discoveries on new functions of this system are still ahead of us. Finally, we present our views on the most promising future avenues of research to deepen our knowledge on creatine and creatine kinase. In particular, we elaborate on how state-of-the-art high-throughput analytical (“omics”) technologies and systems biology approaches may be used successfully to unravel the complex network of interdependent physiological functions related to creatine and creatine kinase

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Authors and Affiliations

  1. DSM Nutritional Products Ltd., Biotechnology R&D, Bldg. 203/17BP.O. Box 3255, CH-4002 Basel, Switzerland

    Markus Wyss

  2. Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH-1011 Lausanne, Switzerland

    Olivier Braissant

  3. Finzelberg GmbH & Co. KG, Koblenzer Straße 48-56, D-56626 Andernach, Germany

    Ivo Pischel

  4. Department of Clinical Chemistry, Metabolic Unit, VU University Medical Center, De Boelelaan 1117, NL-1081 HV Amsterdam, The Netherlands

    Gajja S. Salomons

  5. Department of Paediatrics Division of Clinical and Metabolic Genetics and Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Avenue, TorontoON. M5G 1X8, Canada

    Andreas Schulze

  6. Department of Pediatrics, Division of Biochemical Diseases, British Columbia Children’s Hospital, University of British Columbia, Vancouver, B.C.V6H 3V4, Canada

    Sylvia Stockler

  7. Institute of Cell Biology, ETH Zurich, Hönggerberg HPM-D24.1, Schafmattstrasse 1, CH-8093 Zurich, Switzerland

    Theo Wallimann

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  1. VU University Medical Center, Amsterdam, The Netherlands

    Gajja S. Salomons

  2. DSM Nutritional Products Ltd, Basel, Switzerland

    Markus Wyss

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Wyss, M. et al. (2007). Creatine and Creatine Kinase in Health and Disease – A Bright Future Ahead?. In: Salomons, G.S., Wyss, M. (eds) Creatine and Creatine Kinase in Health and Disease. Subcellular Biochemistry, vol 46. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6486-9_16

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