Regular ArticlesEffects of Peroxisome Proliferator-activated Receptor-γ (PPAR-γ) on the Expression of Inflammatory Cytokines and Apoptosis Induction in Rheumatoid Synovial Fibroblasts and Monocytes
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2022, PhytomedicineCitation Excerpt :The reduction of TNF-α was related to the reduction of NF-κB (p65) immunocontent and a reduction in the expression of glucose regulatory protein 78 (GRP78), a transmembrane-bound protein resident in the endoplasmic reticulum, which is related to the production of pro-inflammatory cytokines (Qin et al., 2017). Moreover, an increase in peroxisome proliferator-activated receptors γ (PPARγ) following the use of dioscin, also contributed to the regulation of cytokine gene expression, being an important therapeutic target in the control of inflammation (Croasdell et al., 2015; Ji et al., 2001). Through the same arthritis model as the previous study, Han et al. (2021) demonstrated that dioscin reduced the levels of TNF-α, IL-1β and IL-6 in the synovial tissue of mice.
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2020, HeliyonCitation Excerpt :Reduction of cholesterol and lipid absorption, adjusting postprandial insulin response, promoting cholesterol conversion to bile acids, and improving gut microbiota can be mediated by the dietary fiber (De Carvalho et al., 2014). Also, beta-carotene has the potential to inhibit atherogenesis in humans (Harari et al., 2008) through improving lipid metabolism, cell migration, apoptosis and inflammation as confirmed by Chinetti et al. (2001); Day et al. (2006); Ji et al. (2001), and Marx et al. (1999), respectively. Insulin resistance and fatty liver can be progressed by lipid accumulation and loss of insulin action caused by the high-fat diet (Satapati et al., 2012).
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2017, Pharmacological ReportsCitation Excerpt :The most exhaustively studied form is PPAR-γ. It has been identified as a transcription factor associated with adipocyte differentiation [7] and is known to be involved in apoptosis, cell cycle control [8] and the inhibition of cytokine secretion from inflammatory cells [9,10]. PPAR-γ is present in human and mouse monocytes/macrophages, and higher expression is observed during monocyte to macrophage differentiation and after cell activation by M-CSF or GM-CSF [11].
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Correspondence to: Jeongwon Sohn, Department of Biochemistry, Korea University College of Medicine, 126-1 Anam-Dong 5-Ga, Sungbuk-Gu, Seoul 136-705, Korea. Fax: (82) 2 922 6702; E-mail:[email protected]