Regular ArticleGlucocorticoid Hormones Upregulate Interleukin 2 Receptor α Gene Expression
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Circulating microparticle subpopulations in systemic lupus erythematosus are affected by disease activity
2017, International Journal of CardiologyCitation Excerpt :Finally, an outstanding point of the findings herein presented is the role of glucocorticoids in the generation of circulating MPs, which in turn could influence lymphocyte activation. Thus, patients under this treatment presented a higher amount of circulating CD25pos-TMPs and increased T cell CD25 expression, consistent with previous data about the role of glucocorticoids upregulating the expression of this molecule [53,54]. Moreover, glucocorticoid-treated patients displayed higher serum levels of IL-10 that were positively correlated with CD25pos-TMPs.
Effect of dexamethasone and meloxicam on counts of selected T lymphocyte subpopulations and NK cells in cattle - In vivo investigations
2014, Research in Veterinary ScienceCitation Excerpt :The drug may induce the expression of CD25 directly, in a manner not associated with T-cell activation. This hypothesis is supported by results of investigations which proved that glucocorticosteroids enhance CD25 expression on different mouse T cell lines, by specifically inducing transcription of the IL-2Rα gene (Lamas et al., 1993). The available literature contains a few reports on the effect of administration of SAIDs on percentages of CD4+, CD8+ and WC1+ T cells in cattle.
In vitro effects of dexamethasone on bovine CD25<sup>+</sup>CD4<sup>+</sup> and CD25<sup>-</sup>CD4<sup>+</sup> cells
2012, Research in Veterinary ScienceCitation Excerpt :Thus, dexamethasone and IL-7 did not induce additional Tregs cells, but additively induced the expression of the activation marker CD25 by CD4+CD25− T cells (Chung et al., 2004). Moreover, it has been shown that glucocorticosteroids enhance the expression of high-affinity IL-2 receptors (CD25) in different mouse T cell lines, by specifically inducing transcription of the IL-2Rα gene (Lamas et al., 1993). However, later, and especially in recent years, opinions about the nature of human and mouse CD4+CD25+ generated with the use of glucocorticosteroids have changed, because the findings of a number of studies have shown or implied (Karagiannidis et al., 2004; Braitch et al., 2009; Provoost et al., 2009; Xie et al., 2009) that those are regulatory cells rather than activated lymphocytes.
Bi-directional effects of stress on immune function: Possible explanations for salubrious as well as harmful effects
2007, Psychoneuroimmunology, Two-Volume SetA potential role for hydrocortisone in the positive regulation of IL-15-activated NK-cell proliferation and survival
2005, BloodCitation Excerpt :A similar GC-mediated enhancing effect on the expression of IL-2Rα21,22 supports the positive modulatory role of GCs on the immune system's function. Given the accumulating evidence of a stress-induced enhancement of immune function,23-29 some direct immune stimulatory effects of GCs have been interpreted in the context of their adoptive actions in the acute phase of a stress response.30 A typical example for the dual action of GCs on the immune system is GC–induced leucine zipper protein (GILZ).