Risk of incident autoimmune disease according to diagnosis of Raynaud phenomenon among patients from the state of California.
| SSc | SLE | DM | PM | Sicca | UCTD | |
|---|---|---|---|---|---|---|
| Unadjusted HR (95% CI) | 1.85 (1.74-1.97) | 1.91 (1.82-2.01) | 2.12 (1.60-2.81) | 2.08 (1.68-2.56) | 1.66 (1.54-1.79) | 1.98 (1.76-2.22) |
| Adjusteda HR (95% CI) | 1.85 (1.74-1.96) | 1.80 (1.71-1.90) | 1.78 (1.31-2.41) | 1.84 (1.46-2.31) | 1.51 (1.40-1.63) | 1.91 (1.69-2.15) |
| IR in exposedb (99% CI) | 26.15 (25.07-27.28) | 29.25 (28.11-30.44) | 1.10 (0.89-1.35) | 1.38 (1.15-1.65) | 11.39 (10.69-12.14) | 6.08 (5.57-6.64) |
| IR in unexposedb (99% CI) | 0.08 (0.07-0.08) | 0.69 (0.67-0.72) | 0.03 (0.02-0.03) | 0.04 (0.03-0.05) | 0.13 (0.12-0.14) | 0.05 (0.04-0.05) |
All P values < 0.001.
↵a Adjusted model included smoking, fibromyalgia, neuropathy, carpal tunnel syndrome, cryoglobulinemia, POEMS syndrome, vasculitis, atherosclerosis, hepatitis B, hepatitis C, cold agglutinin disease, hypothyroidism, malignancy, nephrogenic systemic fibrosis, eosinophilic fasciitis, eosinophilic myalgia syndrome, and drug-induced lupus.
↵b New cases per thousand person-years. DM: dermatomyositis; HR: hazard ratio; IR: incidence rate; POEMS: polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes; PM: polymyositis; sicca: sicca syndrome; SLE: systemic lupus erythematosus; SSc: systemic sclerosis; UCTD: undifferentiated connective tissue disease.