Table 3.

Performance of different HF definitions in RA against Framingham criteria for HF.

DefinitionSensitivity,
rate (95% CI)
Specificity,
rate (95% CI)
PPV,
rate (95% CI)
NPV,
rate (95% CI)
Accuracy,
rate (95% CI)
True
Positive, n
True
Negative, n
False
Positive, n
False
Negative, n
All HF, regardless of LVEF
      Physician diagnosis of HF98.22
(94.90-99.63)
96.32
(94.65-97.58)
86.46
(80.79-90.96)
99.56
(98.72-99.91)
96.69
(95.27-97.77)
166680263
      Physician diagnosis of HF,
      inpatient only
66.67
(59.07-73.68)
98.16
(96.88-99.02)
89.76
(83.13-94.44)
92.42
(90.29-94.21)
92.04
(90.05-93.74)
1146951357
      1 ICD-9/10
      code for HF
89.94
(84.17-94.14)
91.79
(89.49-93.72)
71.50
(64.71-77.64)
97.55
(96.05-98.59)
91.44
(89.36-93.23)
1436375716
      2 ICD-9/10
      codes for HF
78.24
(71.27-84.19)
95.62
(93.83-97.00)
81.10
(74.26-86.78)
94.81
(92.92-96.32)
92.25
(90.27-93.93)
1336763137
LVEF ≥ 50% (HFpEF)
      Physician diagnosis of HF98.65
(92.70-99.97)
98.53
(97.38-99.26)
86.90
(77.78-93.28)
99.86
(99.25-99.99)
98.54
(97.46-99.24)
73735111
      Physician diagnosis of HF,
      inpatient only
62.50
(50.96-73.08)
99.34
(98.46-99.78)
90.91
(80.05-96.98)
96.15
(94.55-97.39)
95.81
(94.22-97.06)
50750530
      1 ICD-9/10
      code for HF
87.88
(77.51-94.62)
96.60
(94.98-97.81)
70.73
(59.65-80.26)
98.84
(97.73-99.50)
95.85
(94.19-97.14)
58681248
      2 ICD-9/10
      codes for HF
77.27
(65.30-86.69)
99.04
(98.03-99.61)
87.93
(76.70-95.01)
97.97
(96.67-98.86)
97.24
(95.85-98.26)
51723715
LVEF < 50% (HFrEF)
      Physician diagnosis of HF92.59
(82.11-97.95)
99.61
(98.86-99.92)
94.34
(84.34-98.82)
99.48
(98.67-99.86)
99.15
(98.25-99.66)
5076334
      Physician diagnosis of HF,
      inpatient only
70.37
(56.39-82.02)
99.74
(99.08-99.97)
95.00
(83.08-99.39)
97.99
(96.75-98.85)
97.84
(96.61-98.72)
38779216
      1 ICD-9/10
      code for HF
80.43
(66.09-90.64)
99.45
(98.59-99.85)
90.24
(76.87-97.28)
98.77
(97.67-99.43)
98.31
(97.13-99.10)
3772149
      2 ICD-9/10
      codes for HF
70.21
(55.11-82.66)
99.60
(98.83-99.92)
91.67
(77.53-98.25)
98.16
(96.93-98.99)
97.86
(96.60-98.75)
33746314
  • HF: heart failure; HFpEF: HF with preserved LVEF; HFrEF: HF with reduced LVEF; ICD-10: International Classification of Diseases, 10th revision; ICD-9: ICD, 9th revision; LVEF: left ventricular EF; NPV: negative predictive value; PPV: positive predictive value; RA: rheumatoid arthritis.