Baseline demographics and disease status of patients in each study.a
| Study 1, n = 696 | Study 2, n = 849 | Study 3, n = 2996 | |
|---|---|---|---|
| Age, yrs | 60.8 (9.6) | 64.9 (9.4) | 60.6 (9.4) |
| Female, n, (%) | 453 (65.1) | 587 (69.1) | 1953 (65.2) |
| Index joint, n, (%) | |||
| Hip | 102 (14.7) | 114 (17.0) | 443 (14.8) |
| Knee | 594 (85.3) | 705 (83.0) | 2553 (85.2) |
| Kellgren-Lawrence grade of index joint, n, (%) | |||
| 0 | 0 | 2 (0.2) | 5 (0.2) |
| 1 | 1 (0.1) | 0 | 7 (0.2) |
| 2 | 184 (26.5) | 166 (19.6) | 892 (29.8) |
| 3 | 304 (43.7) | 375 (44.2) | 1425 (47.6) |
| 4 | 206 (29.6) | 306 (36.0) | 667 (22.3) |
| Disease duration, yrs | 9.3 (8.4) | 7.5 (7.0) | 8.8 (8.3) |
| WOMAC Pain | 7.2 (1.2) | 6.6 (0.9) | 7.0 (1.1) |
| WOMAC Physical Function | 7.3 (1.1) | 6.7 (0.9) | 7.1 (1.1) |
| PGA-OA | 3.5 (0.6) | 3.6 (0.6) | 3.5 (0.6) |
Values are expressed as mean (SD) unless otherwise indicated.
↵aData were analysed from 688, 844 and 2948 patients from studies 1, 2, and 3, respectively. Patients without data available at all timepoints in the respective studies were excluded from the analyses. PGA-OA: patient global assessment of osteoarthritis; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index.