Incidence and HR for site-specific cancers in 1:2 matched cohorts aged 41–55 years.
| Site | Non-gout, n = 8352 | Gout, n = 4176 |
|---|---|---|
| Stomach | ||
| Events | 82 | 69 |
| Rate per 1000 PY | 0.943 | 1.579 |
| HR (95% CI)a | Ref | 1.710 (1.221–2.395)* |
| Esophagus | ||
| Events | 6 | 3 |
| Rate per 1000 PY | 0.069 | 0.068 |
| HR (95% CI)b | Ref | 0.839 (0.194–3.629) |
| Colon, rectum | ||
| Events | 91 | 38 |
| Rate per 1000 PY | 1.047 | 0.866 |
| HR (95% CI)b | Ref | 0.697 (0.469–1.035) |
| Liver | ||
| Events | 69 | 35 |
| Rate per 1000 PY | 0.792 | 0.797 |
| HR (95% CI)b | Ref | 0.995 (0.649–1.524) |
| Urologic | ||
| Events | 30 | 21 |
| Rate per 1000 PY | 0.344 | 0.478 |
| HR (95% CI)b | Ref | 1.246 (0.696–2.232) |
| Gallbladder, biliary tract, pancreas | ||
| Events | 18 | 18 |
| Rate per 1000 PY | 0.206 | 0.409 |
| HR (95% CI)b | Ref | 1.851 (0.939–3.648) |
| Lung | ||
| Events | 56 | 42 |
| Rate per 1000 PY | 0.643 | 0.958 |
| HR (95% CI)b | Ref | 1.494 (0.985–2.267) |
| Head and neck | ||
| Events | 29 | 26 |
| Rate per 1000 PY | 0.333 | 0.593 |
| HR (95% CI)b | Ref | 1.850 (1.071–3.196)* |
| Thyroid | ||
| Events | 86 | 55 |
| Rate per 1000 PY | 0.99 | 1.257 |
| HR (95% CI)b | Ref | 1.274 (0.898–1.806) |
| Sex-specific organs, femalec | ||
| Events | 43 | 22 |
| Rate per 1000 PY | 0.494 | 0.501 |
| HR (95% CI) b | Ref | 1.093 (0.646–1.847) |
| Sex-specific organs, maled | ||
| Events | 61 | 32 |
| Rate per 1000 PY | 0.701 | 0.729 |
| HR (95% CI)b | Ref | 0.926 (0.588–1.456) |
| Hematologic or lymphoid | ||
| Events | 7 | 10 |
| Rate per 1000 PY | 0.08 | 0.227 |
| HR (95% CI)b | Ref | 2.849 (1.035–7.844)* |
| Other sites | ||
| Events | 33 | 19 |
| Rate per 1000 PY | 0.379 | 0.432 |
| HR (95% CI)b | Ref | 0.977 (0.542–1.761) |
↵* Significant.
↵a HR from the Cox proportional hazards regression model, adjusted for residence, income, smoking, drinking, comorbidities (DM, hypertension, kidney disease, COPD, Helicobacter pylori·-related diseases including peptic ulcers), BMI, SBP, DBP, glucose, total cholesterol, and hemoglobin.
↵b HR from the Cox proportional hazards regression model, adjusted for residence, income, smoking, drinking, comorbidities (DM, hypertension, kidney disease, and COPD), BMI, SBP, DBP, glucose, total cholesterol, and hemoglobin.
↵c Breast and female genital organs.
↵d Prostate, and other male genital organs. COPD: chronic obstructive pulmonary disease; DBP: diastolic blood pressure; DM: diabetes mellitus; PY: person-years; SBP: systolic blood pressure.