Table 2.

Risk of incident CVD and revascularization procedures in RA by decade of RA incidence.

Event Type	Decade	Total^{^a} (Events)	HR (95% CI)^{^b}	P	HR (95% CI)^{^c}	P	HR (95% CI)^{^d}	P	HR (95% CI)^{^e}	P
Any CVD event (Ml/stroke)	1980–89	191 (48)	Ref	–	Ref	–	Ref	–	Ref	–
	1990–99	291 (47)	0.84 (0.55–1.29)	0.43	0.89 (0.57–1.39)	0.60	0.87 (0.56–1.36)	0.55	1.02 (0.63–1.64)	0.94
	2000–09	392 (25)	0.58 (0.34–0.98)	0.04	0.53 (0.31–0.93)	0.03	0.63 (0.37–1.08)	0.10	0.64 (0.34–1.22)	0.18
MI	1980–89	195 (26)	Ref	–	Ref	–	Ref	–	Ref	–
	1990–99	292 (24)	0.82 (0.45–1.49)	0.51	0.77 (0.41–1.45)	0.43	0.76 (0.41–1.40)	0.38	0.95 (0.48–1.86)	0.87
	2000–09	394 (10)	0.44 (0.20–0.97)	0.04	0.36 (0.16–0.81)	0.01	0.45 (0.20–0.99)	0.046	0.47 (0.18–1.19)	0.11
Stroke (ischemic or hemorrhagic)	1980–89	196 (27)	Ref	–	Ref	–	Ref	–	Ref	–
	1990–99	297 (28)	0.84 (0.48–1.46)	0.53	0.95 (0.53–1.70)	0.86	0.97 (0.54–1.73)	0.91	1.05 (0.57–1.94)	0.87
	2000–09	402 (18)	0.75 (0.38–1.45)	0.38	0.77 (0.38–1.56)	0.47	0.88 (0.44–1.73)	0.70	0.92 (0.41–2.04)	0.83
MI/revascularization procedure	1980–89	194 (36)	Ref	–	Ref	–	Ref	–	Ref	–
	1990–99	281 (37)	0.83 (0.51–1.33)	0.43	0.82 (0.49–1.34)	0.42	0.81 (0.49–1.32)	0.40	0.99 (0.58–1.71)	0.97
	2000–09	382 (13)	0.36 (0.18–0.70)	0.003	0.30 (0.15–0.59)	< 0.001	0.37 (0.19–0.72)	0.003	0.40 (0.18–0.87)	0.02

↵^a Excludes patients with events prior to RA incidence/index.
↵^b Adjusted for age and sex.
↵^c Adjusted for age, sex, current and former smoking, obesity, DM, HTN, and dyslipidemia.
↵^d Adjusted for age, sex, and highest ESR.
↵^e Adjusted for age, sex, current and former smoking, obesity, DM, HTN, dyslipidemia, time-dependent methotrexate, time-dependent hydroxychloroquine, time-dependent other cDMARDs, and time-dependent bDMARDs. bDMARD: biologic DMARD; cDMARD: conventional DMARD; CVD: cardiovascular disease; DM: diabetes mellitus; DMARD: disease-modifying antirheumatic drug; ESR: erythrocyte sedimentation rate; HTN: hypertension; MI: myocardial infarction; RA: rheumatoid arthritis.