Table 3.

Risk of incident CVD in patients with RA vs non-RA subjects by decade of RA incidence/index.

Outcome	Decade	Total^{^a} (Event) in RA	Total^{^a} (Event) in Non-RA	HR (95% CI)^{^b}	P	HR (95% CI)^{^c}	P
Any CVD event	1980–1989	191 (48)	192 (38)	1.66 (1.08–2.56)	0.02	1.46 (0.94–2.27)	0.10
	1990–1999	291 (47)	278 (24)	2.08 (1.27–3.40)	0.004	1.91 (1.15–3.18)	0.01
	2000–2009	392 (25)	385 (32)	0.71 (0.42–1.19)	0.19	0.71 (0.42–1.19)	0.20
MI	1980–1989	195 (26)	197 (21)	1.59 (0.89–2.85)	0.12	1.36 (0.74–2.48)	0.32
	1990–1999	292 (24)	287 (16)	1.60 (0.85–3.01)	0.15	1.31 (0.68–2.54)	0.42
	2000–2009	394 (10)	393 (16)	0.58 (0.26–1.28)	0.18	0.57 (0.26–1.27)	0.17
Stroke (ischemic or hemorrhagic)	1980–1989	196 (27)	196 (23)	1.51 (0.86–2.65)	0.15	1.29 (0.72–2.29)	0.40
	1990–1999	297 (28)	289 (14)	2.27 (1.19–4.32)	0.01	2.25 (1.16–4.34)	0.02
	2000–2009	402 (18)	396 (22)	0.78 (0.42–1.45)	0.43	0.79 (0.42–1.48)	0.46
MI/revascularization	1980–1989	194 (36)	194 (31)	1.37 (0.85–2.23)	0.20	1.10 (0.67–1.81)	0.71
	1990–1999	281 (37)	284 (20)	2.09 (1.21–3.60)	0.008	1.64 (0.94–2.87)	0.08
	2000–2009	382 (13)	388 (20)	0.62 (0.31–1.25)	0.18	0.62 (0.31–1.26)	0.19

↵^a Excludes patients with events prior to RA incidence/index.
↵^b Adjusted for age and sex.
↵^c Adjusted for age, sex, current and former smoking, obesity, diabetes mellitus, hypertension, and dyslipidemia. CVD: cardiovascular disease; MI: myocardial infarction; RA: rheumatoid arthritis.