Median time to first infection for Cmaxss quartiles.
| Exposure Quartile | Cmaxss Range, μg/mLa | Time to First Infection, Days, Median (95% CI) | Log-rank P |
|---|---|---|---|
| Pooled SC and IV, 2–17 yrs | |||
| Q1 | [19.1–49.7] | 244 (129–462) | 0.45 |
| Q2 | (49.7–65.8] | 152 (106–216) | |
| Q3 | (65.8–198.0] | 162 (91–246) | |
| Q4 | (198.0–307.0] | 186 (82–224) | |
| SC, 2–5 yrs | |||
| Q1 | [37.7–54.4] | 77 (10–511) | 0.93 |
| Q2 | (54.4–61.1] | 77 (27–439) | |
| Q3 | (61.1–69.2] | 87 (36–200) | |
| Q4 | (69.2–119.0] | 67 (25–245) | |
| SC, 6–17 yrs | |||
| Q1 | [19.1–42.4] | 430 (156–577) | 0.48 |
| Q2 | (42.4–52.8] | 108 (63–291) | |
| Q3 | (52.8–62.5] | 204 (113–466) | |
| Q4 | (62.5–101.0] | 266 (152–448) | |
| IV, 6–17 yrs | |||
| Q1 | [119.0–192.5] | 188 (91–473) | 0.50 |
| Q2 | (192.5–214.5] | 76 (51–211) | |
| Q3 | (214.5–238.5] | 186 (49–684) | |
| Q4 | (238.5–307.0] | 192 (81–224) | |
Q1 and Q4 represent the lowest and the highest quartile, respectively.
↵a For PK ranges, a square bracket indicates respective endpoint is included in the interval. A round bracket indicates respective endpoint is not included in the interval. Cmaxss: steady-state maximum serum concentration; IV: intravenous; PK: pharmacokinetic; Q: quartile; SC; subcutaneous.