Adjusted ORa of 2 or more prescriptions among adults with AS or PsA stratified by NSAID use within 6 months of THA or TKA (secondary outcome).
| No. Prescriptions Per Drug Category | AS | PsA | ||
|---|---|---|---|---|
| NSAID Use | No NSAID Use | NSAID Use | No NSAID Use | |
| 2+ NSAID/0 TNFi/0 DMARD | 1.0 | 1.0 | 1.0 | 1.0 |
| 2+ NSAID/0 TNFi/2+ DMARD | 0.81 (0.46–1.40) | 0.81 (0.45–1.46) | 0.79 (0.59–1.06) | 0.80 (0.60–1.06) |
| 2+ NSAID/2+ TNFi/0 DMARD | 1.08 (0.62-1.88) | 1.16 (0.62–2.18) | 0.99 (0.69–1.44) | 0.76 (0.54–1.08) |
| 2+ NSAID/2+ TNFi/2+ DMARD | 0.52 (0.23–1.19) | 2.14 (0.95–4.83) | 1.02 (0.69–1.53) | 1.30 (0.88–1.92) |
Values are OR (95% CI).
↵aAdjusted for age, chronic kidney disease, diabetes, liver disease, peptic ulcer disease, psoriasis (PsA subjects only), rheumatoid arthritis, erythrocyte sedimentation rate, C-reactive protein, and rheumatology visit prior to study eligibility. AS: ankylosing spondylitis; DMARD: disease-modifying antirheumatic drug; NSAID: nonsteroidal antiinflammatory drug; PsA: psoriatic arthritis; THA: total hip arthroplasty; TKA: total knee arthroplasty; TNFi: tumor necrosis factor inhibitor.