Summary of top canonical pathways identified with Ingenuity Pathway Analysis (IPA).
| Canonical Pathway | P | Z |
|---|---|---|
| SPINK1 pancreatic cancer pathway | 4.35 × 10–5 | –3.273 |
| Calcium signaling | 7.74 × 10–5 | 1.372 |
| Pancreatic adenocarcinoma | 2.02 × 10–4 | 3.695 |
| Axonal guidance signaling | 5.18 × 10–4 | NA |
| Glutamate receptor signaling | 6.35 × 10–4 | 2.121 |
| LPS/IL-1–mediated inhibition of RXR function | 6.52 × 10–4 | –2.353 |
| ESR1 | 2.32 × 10–12, with predicted inhibition | |
| CTNNβ1 | 9.31 × 10–12, with predicted activation | |
| CREB1 | 2.74 × 10–9, with predicted activation | |
| ERBB2 | 3.05 × 10–9 |
CREB1: cAMP responsive element-binding protein 1; CTNNB1: Catenin β-1; ERBB2: erb-B2 receptor tyrosine kinase 2; ESR1: estrogen receptor 1; LPS/IL-1: lipopolysaccharide/interleukin-1; NA: not available; RXR: retinoid X receptor; SPINK1: serine peptidase inhibitor kazal type 1.