Changes of serum biomarkers highly related to the progress of OA in participant serum.
| Serum | Before Treatment | After Treatment | ||||||
|---|---|---|---|---|---|---|---|---|
| Biomarkers, pg/mL | Laser, n = 56 | Sham, n = 57 | z | P | Laser, n = 56 | Sham, n = 57 | z | P |
| COMP | 288.3 (251.0, 340.0) | 291.0 (253.0, 414.1) | –0.815 | 0.42 | 270.2 (240.7, 305.9) | 301.0 (260.2, 364.3) | –2.398 | 0.02 |
| IL-1β | 3.0 (0.8, 7.3) | 1.5 (1.2, 13.5) | –0.830 | 0.46 | 2.5 (0.8, 5.7) | 1.3 (0.6, 3.67) | –0.166 | 0.87 |
| IL-2 | 27.3 (15.4, 68.7) | 19.2 (7.4, 74.9) | –1.280 | 0.20 | 33.2 (15.0, 76.8) | 16.8 (8.4, 68.3) | –1.108 | 0.27 |
| IL-6 | 5.2 (2.1, 11.1) | 11.8 (4.8, 51.1) | –1.513 | 0.13 | 4.6 (2.5, 9.8) | 4.7 (2.1, 13.6) | –0.998 | 0.32 |
| IL-8 | 61.3 (10.5, 169.2) | 111.2 (24.3, 164.6) | –1.232 | 0.22 | 50.8 (17.0, 170.4) | 25.2 (10.0, 62.3) | –1.049 | 0.29 |
| MCP-1 | 130.1 (89.3, 164.4) | 126.6 (97.6, 177.7) | –0.735 | 0.46 | 110.4 (89.1, 140.5) | 111.4 (82.7, 150.7) | –0.235 | 0.81 |
| MMP-3 | 62 (4.2, 14.3) | 6.79(4.52, 11.2) | –0.295 | 0.77 | 6.2 (4.1, 12.3) | 7.0 (4.6, 9.8) | –0.027 | 0.98 |
| MMP-13 | 162.6 (50.5, 267.7) | 83.3 (38.5, 356.8) | –0.880 | 0.38 | 206.7 (132.8, 275.8) | 120.8 (42.4, 245.4) | –0.454 | 0.65 |
Values are median (Q1, Q3). The Mann-Whitney U test was performed for the analysis. COMP: cartilage oligomeric matrix protein; IL: interleukin; MCP: monocyte chemoattractant protein; MMP: matrix metallopeptidase; OA: osteoarthritis.