Clinical characteristics of GPA cohort as extracted from medical files, and of the RA and population controls as registered in EIRA-1.
| GPA | RA | Population Controls | |
|---|---|---|---|
| Total, n | 62 | 128 | 248 |
| Age at disease onset, yrs, range (mean)a | 17–79 (52.8) | 19–69 (50.3) | 19–70 (52.2) |
| Sex, female/male | 32/30 | 66/62 | 116/132 |
| Positive biopsy | 51 (82) | – | |
| ENT involvement | 56 (90.3) | – | |
| Pulmonary involvement | 46 (74.3) | – | |
| Renal involvement | 23 (37.1) | – | |
| ANCA-positive | 62 (100) | – | |
| PR3-ANCA–positive | 61 (98.4) | – | |
| MPO-ANCA–positive | 1 (1.6) | – | |
| RF- and/or ACPA-positive | – | 128 (100) | |
| RF-positive | – | 118 (92.2) | |
| ACPA-positive | – | 107 (83.6) |
Values are expressed as n (%) unless otherwise indicated.
↵aAge at disease onset for patients with GPA and RA controls; population controls were age-matched to patients with RA. ANCA: antineutrophil cytoplasmic antibody; ACPA: anticitrullinated protein antibodies; EIRA-1: Epidemiological Investigation of Rheumatoid Arthritis study 1; GPA: granulomatosis with polyangiitis; MPO: myeloperoxidase; PR3: proteinase 3; RA: rheumatoid arthritis; RF: rheumatoid factor.