Correlation coefficient (r) and P values of sLRP1 with inflammatory biomarkers for each JIA category at enrollment.
| Biomarker | JIA Categories | ||||
|---|---|---|---|---|---|
| RF-Polyarthritis, n = 41 | Oligoarthritis, n = 26 | PsA, n = 9 | ERA, n = 8 | ||
| r (P) | |||||
| Age | –0.469 (0.02) | ||||
| Exotoxina | 0.465 (0.02) | ||||
| MMP-2a | –0.881 (0.004) | ||||
| MMP-10a | –0.905 (0.002) | ||||
| MMP-12a | 0.850 (0.004) | ||||
| MMP-13a | 0.733 (0.03) | ||||
| G-CSFa | 0.550 (0.004) | ||||
| GM-CSFa | 0.474 (0.02) | ||||
| FGF-2a | 0.326 (0.046) | 0.455 (0.02) | |||
| IFN-αb | 0.484 (0.002) | 0.611 (0.001) | 0.867 (0.002) | ||
| IFN-γa | 0.400 (0.01) | 0.518 (0.007) | |||
| IL-10c | 0.674 (< 0.001) | ||||
| IL-12p40c | 0.534 (0.009) | ||||
| IL-12p70a | 0.512 (0.009) | ||||
| IL-13a | 0.519 (0.003) | 0.734 (< 0.001) | 0.857 (0.01) | ||
| IL-15a | 0.611 (0.02) | ||||
| IL-17a | 0.667 (0.05) | ||||
| IL-1Rac | 0.700 (0.003) | ||||
| IL-1aa | 0.447 (0.009) | 0.764 (< 0.001) | |||
| IL-2c | 0.552 (0.01) | 0.679 (0.008) | |||
| IL-4c | 0.719 (0.001) | ||||
| IL-5a | 0.779 (< 0.001) | ||||
| IL-6a | 0.502 (0.03) | ||||
| IL-7a | 0.411 (0.04) | 0.412 (0.04) | 0.905 (0.002) | ||
| IL-8a | –0.764 (0.03) | ||||
| TNF-αa | 0.554 (0.004) | ||||
| TNF-βa | 0.800 (< 0.001) | 0.886 (0.02) | |||
| VEGFa | 0.440 (0.02) | ||||
Biomarker levels are reported in ng/mL. Significance level was < 0.05. Only significant correlations are shown.
↵a Proinflammatory mediator.
↵b Mediators having both pro- and antiinflammatory actions.
↵c Antiinflammatory mediator. ERA: enthesitis-related arthritis; FGF-2: fibroblast growth factor 2; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; IFN: interferon; IL: interleukin; JIA: juvenile idiopathic arthritis; MMP: matrix metalloproteinases; PsA: psoriatic arthritis; sLRP1: soluble low-density lipoprotein receptor-related protein l; TNF: tumor necrosis factor; VEGF: vascular endothelial growth factor.