First Author, Country, Year | SSc Patients, n | Mitral Regurgitation | Mitral Stenosis | Aortic Regurgitation | Aortic Stenosis |
---|---|---|---|---|---|
Candell-Riera, et al19, Spain, 1996 | Patients with limited SSc: 63; healthy controls: 26 | Total: 49% P < 0.0001, compared with healthy controls (8%) OR adjusted for age: 6.1 (95% CI 1.6–23) | NA | NA | NA |
de Groote, et al21, France, 2007 | 570 patients (diffuse: 150, limited: 420) without severe pulmonary function abnormalities, severe cardiac disease, and known PAH | Degree II: 38 (6.7%) Degree: III–IV: 2 (0.4%) Total (any degree): 40 (7.01%) Only moderate to severe: 2 (0.4%) | 0 (0%) | Degree II: 14 (2.5%) Degree III–IV: 0 (0%) Total (any degree): 14 (2.5%) Only moderate to severe: 0 | Aortic stenosis < 1 cm2 was noted in 19 (3.3%) patients |
Meune, et al22, France, 2008 | Patients without pulmonary arterial hypertension or clinical manifestations of heart failure: 100 (diffuse: 42, limited: 58); number of healthy controls: 26 | Degree I: 45% Degree II: 3% Total (any degree): 48 (48%) Only moderate: 3 (3%) P not significant compared with healthy controls (30.7%) | Total: 2 (2%) | Degree I: 15% Degree II: 3% Total (any degree): 18 (18%) Only moderate: 3 (3%) P = 0.023, compared with healthy controls (0%) | Total: 3 % |
Muresan, et al23, Romania, 2016 | 110 (diffuse: 47, limited: 63) | 12 (10.9%) | 2 (0.2%) | 4 (3.6%) | 4 (3.6%) |
Fernández Codina, et al28, Spain, 2017 | 173 patients (diffuse: 37, limited: 116, sine scleroderma: 20) | Any degree: 116 (67%) | NA | Any degree: 52 (30%) | NA |
Nordin, et al24, Sweden, 2017 | 110 patients (diffuse: 22, limited: 78); healthy controls: 105 | Any degree: 2 (1.8%) P = 0.03 compared with controls | NA | Any degree: 1 (0.9%) P = 0.06 compared with controls | NA |
Butt, et al8, Denmark, 2019 | SSc patients: 2278; controls: 13.890 | OR adjusted for age and sex: 2.03 (95% CI 1.07–3.87) | OR adjusted for age and sex: 3.33 (95% CI 1.78–5.63) | OR adjusted for age and sex: 3.17 (95% CI: 0.56–19.95) | OR adjusted for age and sex: 2.18 (95% CI 1.18–4.02) |
Elnagar, et al25, USA, 2019 | 506 | Total: 121 (24%) Mild: 99 (19.5%) Moderate: 18 (3.5%) Severe: 4 (0.8%) | Total: 1 (0.2%) Moderate: 1 (0.2%) | Total: 39 (7.7%) Mild: 36 (7%) Moderate: 3 (1%) Severe: 0% | Total: 6 (1.2%) Mild: 3 (1%) Moderate: 1 (0.2%) Severe: 2 (0.4%) |
Kurmann, et al26, USA, 2018 | SSc patients: 79; controls: 158 | Prevalence of moderate/severe valvular heart disease (unspecified type of lesion): | |||
SSc: 11% | Controls: 3% | P = 0.011 |
NA: not analyzed; ND: not done; PAH: pulmonary arterial hypertension.