Main results of studies that analyzed the incidence of mitral and aortic valve disease in SSc.
| Incidence | |||
|---|---|---|---|
| SSc Cases, Incidence Rate per 100 PY (95% CI) | Controls, Incidence Rate per 100 PY (95% CI) | Analysis of Differences, P or HR | |
| Butt, et al8, Denmark, 1995–2015 | |||
| SSc patients, n = 2278 | |||
| Controls, n = 13,890 | |||
| Mitral regurgitation (any degree) | 0.18 (0.14–0.24) | 0.04 (0.03–0.05) | HR 4.60; 95% CI 3.12–6.79 |
| Mitral stenosis (any degree) | 0.02 (0.01–0.05) | NA (≤ 3 incident cases) | NS |
| Aortic regurgitation (any degree) | 0.16 (0.12–0.22) | 0.04 (0.03–0.05) | HR 3.78; 95% CI 2.55–5.58 |
| Aortic stenosis (any degree) | 0.29 (0.23–0.36) | 0.10 (0.08–0.12) | HR 2.99; 95% CI 2.025–3.97 |
| Alvarado, et al27, Argentina, 2000–2017 | |||
| SSc patients, n = 127 | |||
| Controls, n = 497 | |||
| Moderate to severe mitral regurgitation | 1.9 (1.3–2.7) | 0.9 (0.7–1.2) | P = 0.01 |
| Moderate to severe mitral stenosis | 0.2 (0.08–0.7) | 0.06 (0.02–0.17) | P = 0.06 |
| Moderate to severe aortic regurgitation | 1.4 (0.1–2.1) | 1.1 (0.8 – 1.4) | P = 0.16 |
| Moderate to severe aortic stenosis | 1.1 (0.7–1.8) | 0.3 (0.2–0.5) | P < 0.001 |
| Elnagar, et al25, USA, 2000–2018 | |||
| SSc patients, n = 506 | |||
| Controls, n = 0 | |||
| Mild mitral regurgitation | 6.36 (5.24–7.59) | ND | |
| Moderate mitral regurgitation | 1.46 (1.03–1.95) | ND | |
| Severe mitral regurgitation | 0.04 (0.00–0.13) | ND | |
| Mild mitral stenosis | 0.21 (0.08–0.42) | ND | |
| Moderate mitral stenosis | 0.07 (0.01–0.20) | ND | |
| Severe mitral stenosis | 0.04 (0.00–0.13) | ND | |
| Mild aortic regurgitation | 1.80 (1.3–2.36) | ND | |
| Moderate aortic regurgitation | 0.29 (0.12–0.52) | ND | |
| Severe aortic regurgitation | 0.00 | ND | |
| Mild aortic stenosis | 1.25 (0.87–1.70) | ND | |
| Moderate aortic stenosis | 0.65 (0.38 – 0.98) | ND | |
| Severe aortic stenosis | 0.28 (0.12 – 0.51) | ND | |
| Kurmann, et al26, USA, 1980–2016 | The cumulative incidence of moderate/severe valvular heart disease (unspecified type of lesion) in patients: | ||
| SSc patients, n = 79 | SSc (after diagnosis): 23.6% (95% CI 14.5–38.4) | Controls: 7.4% (95% CI 4.0–13.5) | HR 2.86; 95% CI 1.38–5.91; P = 0.004 |
| Controls, n = 158 | |||
NA: not analyzed; ND: not done; NS: not significant; PAH: pulmonary arterial hypertension; PY: person-years.