Pulmonary function test (PFT) results in pSS patients with COPD (n = 16) and ILD signs (n = 15) at follow-up.
| Baseline | Follow-up | P | |
|---|---|---|---|
| Patients with pSS and COPD at follow-up, n = 16 | |||
| VC | 96 (85–106) | 97 (81–109) | 0.78 |
| TLC | 101 (87–113) | 98 (86–108) | 0.01 |
| RV | 110 (98–134)* | 101 (88–114) | 0.001 |
| RV/TLC ratio | 116 (99–129)* | 107 (92–123) | < 0.001 |
| FEV1 | 85 (70–88)*** | 77 (67–94)*** | 0.53 |
| FEV1/VC ratio | 86 (79–98)*** | 87 (79–95)*** | 0.98 |
| DLCO | 88 (78–99)** | 92 (71–99)* | 0.67 |
| COPD, n (% of COPD+ at FU) | 13 (81) | 16 (100) | 0.25 |
| Mild COPD, n (% of COPD+ at FU) | 8 (50) | 7 (44) | > 0.99 |
| Moderate COPD, n (% of COPD+ at FU) | 5 (31) | 9 (56) | 0.13 |
| Severe and very severe COPD, n (% of COPD+ at FU) | 0 (0) | 0 (0) | N/A |
| Patients with pSS and radiographic ILD signs at follow-up, n = 15 | |||
| VC | 88 (82–102)* | 91 (83–97)* | 0.87 |
| TLC | 97 (87–107) | 95 (86–103) | 0.03 |
| RV | 113 (98–140)* | 101 (87–127) | 0.001 |
| RV/TLC ratio | 117 (104–131)** | 109 (92–122) | 0.001 |
| FEV1 | 81 (74–91)** | 78 (74–96)** | > 0.99 |
| FEV1/VC ratio | 95 (85–99)** | 96 (79–102) | 0.65 |
| DLCO | 91 (78–103)* | 85 (76–98)* | 0.28 |
Values are presented as median % of predicted values (IQR) unless otherwise specified. Results of PFT at baseline in 2012 compared to follow-up in 2018, presented as percentages of predicted values, among the 16 patients with pSS and COPD at follow-up and the 15 patients with pSS and radiographic ILD signs at follow-up.
↵* P < 0.05, actual vs predicted values.
↵** P < 0.01, actual vs predicted values.
↵*** P < 0.001, actual vs predicted values. COPD: chronic obstructive pulmonary disease; ILD: interstitial lung disease; DLCO: diffusing capacity for carbon monoxide; FEV1: forced expiratory volume in 1 second; FU: follow-up; N/A: not assessed; PFT: pulmonary function test; pSS: primary Sjögren syndrome; RV: residual volume, TLC: total lung capacity; VC: vital capacity.