Allelic associations (OR and 95% CI) comparing atopic dermatitis (AD) to controls and allelic frequencies (AF) for RA HLA-DRB1 risk alleles.
| Allele | OR (95% CI) | AF AD (95% CI) | AF Controls (95% CI) |
|---|---|---|---|
| DRB1*01:01 | 0.76 (0.50–1.14) | 0.07 (0.05–0.09) | 0.09 (0.07–0.12) |
| DRB1*01:02 | 0.92 (0.40–2.12) | 0.02 (0.01–0.03) | 0.02 (0.01–0.04) |
| DRB1*04:01 | 0.90 (0.57–1.43) | 0.07 (0.05–0.09) | 0.08 (0.05–0.11) |
| DRB1*04:02 | 0.43 (0.13–1.41) | 0.01 (0.00–0.01) | 0.01 (0.01–0.03) |
| DRB1*04:03 | 0.52 (0.10–2.58) | 0.00 (0.00–0.01) | 0.01 (0.00–0.02) |
| DRB1*04:04 | 1.81 (0.93–3.53) | 0.05 (0.03–0.07) | 0.03 (0.01–0.05) |
| DRB1*04:05 | 0.69 (0.15–3.12) | 0.00 (0.00–0.01) | 0.01 (0.00–0.02) |
| DRB1*04:07 | 3.69 (0.45–30.18) | 0.01 (0.00–0.02) | 0.00 (0.00–0.01) |
| DRB1*04:08^ | 2.01 (0.22–∞) | 0.00 (0.00–0.01) | 0.00 (0.00–0.01) |
| DRB1*09:01 | 2.30 (0.65–8.14) | 0.02 (0.01–0.03) | 0.01 (0.00–0.02) |
| DRB1*10:01 | 0.83 (0.27–2.57) | 0.01 (0.00–0.02) | 0.01 (0.00–0.03) |
| DRB1*16:01 | 1.04 (0.46–2.37) | 0.02 (0.01–0.03) | 0.02 (0.01–0.04) |
| SE | 1.19 (0.83–1.71) | 0.27 (0.23–0.32) | 0.24 (0.18–0.30) |
The highest risk alleles in RA include -04:01, -04:10, -04:08, -04:05, -04:04, -04:06, -04:11, -04:15, and -10:01, and are also referred to as shared epitope (SE).5 AF of ≥ 0.05 in bold.
↵^ Exact logistic regression. No P < 0.05.