Amino acid residues at location 11, 13, 71, and 74 for HLA-DRB1 known to increase risk of RA5.
| Residues (11/13/71/74) | OR (95% CI) | CF Controls, n = 216 | CF AD, n = 415 | DRB1 Allele |
|---|---|---|---|---|
| HLA-DRB1 | ||||
| VHKA | 0.90 (0.57–1.43) | 0.08 (0.05–0.10) | 0.07 (0.05–0.09) | -04:01 |
| VHRA | 1.59 (0.93–2.68) | 0.04 (0.03–0.07) | 0.07 (0.05–0.09) | -04:10, -04:08, -04:05, -04:04, -04:06, -04:11, -04:15, -10:01 |
| LFRA | 0.78 (0.53–1.14) | 0.11 (0.08–0.15) | 0.09 (0.07–0.11) | -01:01, -01:02 |
| PRRA | 0.85 (0.39–1.80) | 0.02 (0.01–0.04) | 0.02 (0.01–0.03) | -16:02 |
| VHRE | 1.44 (0.45–4.59) | 0.01 (0.00–0.02) | 0.01 (0.01–0.02) | -04:03, -04:07, -04:92 |
| NFRE | 2.30 (0.65–8.14) | 0.01 (0.00–0.02) | 0.02 (0.01–0.03) | -09:01 |
| VHEA | 0.43 (0.13–1.42) | 0.01 (0.00–0.03) | 0.01 (0.00–0.01) | -04:02 |
| SSKA | 0.86 (0.31–2.41) | 0.01 (0.00–0.03) | 0.01 (0.00–0.02) | -13:03 |
| PRAA | 1.10 (0.79–1.52) | 0.14 (0.10–0.17) | 0.15 (0.12–0.17) | -15:01, -15:02, -15:03 |
| GYRQ | 1.17 (0.80–1.70) | 0.11 (0.08–0.14) | 0.12 (0.10–0.14) | -07:01 |
| SSRA | 1.10 (0.80–1.59) | 0.13 (0.10–0.16) | 0.13 (0.11–0.15) | -11:01, -11:04, -12:01, -12:02 |
| SSRE | 0.73 (0.36–1.48) | 0.03 (0.02–0.05) | 0.02 (0.01–0.04) | -14:01, -14:54, -14:04 |
| SGRL | 0.83 (0.27–2.57) | 0.01 (0.00–0.03) | 0.01 (0.00–0.02) | -01:03 |
| SSKR | 0.82 (0.57–1.19) | 0.12 (0.09–0.16) | 0.10 (0.08–0.13) | -03:01, -03:02 |
| SSEA | 1.03 (0.71–1.50) | 0.11 (0.08–0.14) | 0.11 (0.09–0.14) | -13:05, -11:02, -11:03, -13:01, -13:02, -11:11, -13:15 |
| HLA -B | ||||
| D | 1.08 (0.74–1.57) | 0.10 (0.07–0.13) | 0.11 (0.09–0.13) | -08:01 |
| HLA-DPB | ||||
| F | 1.09 (0.90–1.32) | 0.46 (0.41–0.51) | 0.49 (0.46–0.52) | -04:02, -16:01, -02:01, -34:01, -40:01, -106:01, -23:01, -51:01, -584:01, -19:01, -416:01, -105:01, -02:02, -05:01, -04:01 |
OR reported for AD risk as compared to controls. Residue CF reported with 95% CI. HLA-DRB1 alleles that contribute to the residue are also listed. Additional risk variants are reported for position 9 for HLA-B and position 9 HLA-DPB1. Amino acids are reported as accepted one letter code. No P < 0.05. Amino acids in boldface: V (valine); L (leucine); S (serine). AD: atopic dermatitis; CF: composite frequency; RA: rheumatoid arthritis.