Age, yrs (SD) | 56.5 (8.0) | 59.5 (7.0) | 62.2 (5.8) | 62.8 (5.6) | 61.7 (5.8) | 62.2 (5.9) | 61.5 (5.7) | 62.7 (5.0) |
BMI, kg/m2 (SD) | 26.9 (4.5) | 30.3 (4.7) | 32.1 (6.6) | 33.2 (6.1) | 29.6 (5.1) | 32.5 (5.2) | 29.9 (5.2) | 32.8 (6.4) |
Sex | | | | | | | | |
Male | 152,311 (47.0) | 5771 (93.9) | 1520 (46.5) | 368 (79.7) | 9927 (43.1) | 529 (86.0) | 957 (50.4) | 86 (84.3) |
Female | 171,709 (53.0) | 374 (6.1) | 1746 (53.5) | 94 (20.3) | 13,081 (56.9) | 86 (14.0) | 942 (49.6) | 16 (15.7) |
Smoker * | 33,351 (10.3) | 554 (9.1) | 293 (9.0) | 30 (6.5) | 1430 (6.2) | 41 (6.7) | 96 (5.1) | 3 (2.9) |
Alcohol frequency * | | | | | | | | |
Daily or almost daily | 68,557 (21.2) | 2,135 (34.8) | 484 (14.8) | 113 (24.5) | 4759 (20.7) | 197 (32.1) | 441 (23.2) | 25 (24.5) |
3–4 times/week | 79,423 (24.5) | 1755 (28.6) | 482 (14.8) | 87 (18.9) | 4886 (21.3) | 155 (25.2) | 387 (20.4) | 28 (27.5) |
1–2 times/week | 86,186 (26.6) | 1375 (22.4) | 725 (22.2) | 121 (26.2) | 5702 (24.8) | 141 (23.0) | 467 (24.6) | 26 (25.5) |
Infrequent # | 68,961 (21.3) | 644 (10.5) | 1010 (30.9) | 92 (20.0) | 568 (24.7) | 83 (13.5) | 437 (23.0) | 14 (13.7) |
Never | 20,685 (6.4) | 230 (3.7) | 563 (17.2) | 48 (10.4) | 1962 (8.5) | 38 (6.2) | 167 (8.8) | 9 (8.8) |
Comorbidities * | | | | | | | | |
Hypercholesterolemia | 34,034 (14.9) | 1563 (25.6) | 1083 (33.4) | 192 (41.6) | 7067 (30.8) | 249 (40.5) | 664 (35.0) | 44 (43.1) |
Hypertension | 63,644 (27.8) | 3113 (51.0) | 2199 (67.9) | 360 (77.9) | 21,707 (94.6) | 578 (94.0) | 1806 (95.3) | 96 (94.1) |
Angina | 9033 (4.0) | 451 (7.4) | 839 (25.9) | 136 (29.4) | 1210 (5.3) | 65 (10.6) | 141 (7.4) | 7 (6.9) |
Myocardial infarction | 6687 (2.9) | 343 (5.6) | 757 (23.4) | 130 (28.1) | 675 (2.9) | 42 (6.8) | 82 (4.3) | 4 (3.9) |
Heart failure | 75 (< 0.1) | 10 (0.2) | 90 (2.8) | 32 (6.9) | 17 (0.1) | 2 (0.3) | 2 (0.1) | 0 (0.0) |
Stroke | 1707 (0.7) | 42 (0.7) | 214 (6.6) | 43 (9.3) | 849 (3.7) | 42 (6.8) | 126 (6.6) | 11 (10.8) |
Transient ischemic attack | 3527 (1.5) | 156 (2.6) | 43 (1.3) | 8 (1.7) | 225 (1.0) | 6 (1.0) | 16 (0.8) | 2 (2.0) |
Renal failure | 336 (0.1) | 69 (1.1) | 58 (1.8) | 28 (6.1) | 41 (0.2) | 9 (1.5) | 4 (0.2) | 1 (1.0) |
Diabetes mellitus | 10,374 (4.5) | 570 (9.3) | 775 (23.9) | 143 (31.0) | 2136 (9.3) | 116 (18.9) | 296 (15.6) | 32 (31.4) |