Gene, SNP | Effect Allele | No Diuretic, n = 330,165 | Loop Diuretic, n = 3,728 | Thiazide Diuretic, n = 23,623 | Thiazide-like Diuretic, n = 2,001 | |||
---|---|---|---|---|---|---|---|---|
OR (95% CI), P | OR (95% CI), P | Interaction P^ | OR (95% CI), P | Interaction P^ | OR (95% CI), P | Interaction P^ | ||
ABCG2, rs2231142 | T | 2.37 (2.24–2.50), 3.10 × 10−209 | 1.93 (1.54–2.43), 1.50 × 10−8 | 0.59 | 2.17 (1.82–2.59), 5.60 × 10−18 | 0.40 | 1.98 (1.26–3.10), 3.04 × 10−3 | 0.43 |
SLC2A9, rs12498742 | A | 3.06 (2.54–3.69), 7.73 × 10−32 | 4.19 (2.02–8.71), 1.23 × 10−4 | 0.15 | 2.59 (1.51–4.44), 5.41 × 10−4 | 0.61 | 3.92 (0.92–16.81), 0.07 | 0.67 |
GCKR, rs1260326 | T | 1.38 (1.30–1.46), 9.94 × 10−29 | 1.13 (0.91–1.40), 0.26 | 0.14 | 1.51 (1.26–1.81), 7.23 × 10−6 | 0.31 | 1.61 (1.01–2.57), 0.04 | 0.46 |
SLC22A12, rs478607 | A | 0.72 (0.62–0.85), 4.74 × 10−5 | 1.55 (0.70–3.43), 0.28 | 0.08 | 0.77 (0.46–1.28), 0.31 | 0.85 | 1.35 (0.31–5.77), 0.69 | 0.36 |
MLXIPL, rs1178977 | A | 1.31 (1.13–1.53), 4.03 × 10−4 | 1.31 (0.71–2.44), 0.39 | 0.99 | 1.02 (0.65–1.60), 0.91 | 0.26 | 1.29 (0.39–4.26), 0.67 | 0.98 |
PDZK1, rs1471633 | A | 1.24 (1.16–1.31), 8.02 × 10−12 | 1.26 (1.00–1.59), 0.05 | 0.49 | 1.29 (1.07–1.57), 0.01 | 0.63 | 1.80 (1.07–3.03), 0.03 | 0.13 |
SLC16A9, rs1171614 | T | 0.81 (0.77–0.86), 1.50 × 10−13 | 0.87 (0.70–1.07), 0.18 | 0.61 | 0.98 (0.83–1.16), 0.81 | 0.04 | 0.69 (0.45–1.07), 0.09 | 0.37 |
SLC17A3, rs1165151 | T | 0.80 (0.76–0.85), 3.99 × 10−15 | 0.91 (0.73–1.13), 0.38 | 0.52 | 0.75 (0.63–0.89), 1.02 × 10−3 | 0.44 | 1.21 (0.77–1.90), 0.42 | 0.08 |
INHBE, rs3741414 | T | 0.83 (0.79–0.87), 8.24 × 10−12 | 0.81 (0.65–0.99), 0.04 | 0.51 | 0.80 (0.67–0.94), 0.01 | 0.66 | 0.75 (0.49–1.14), 0.18 | 0.46 |
SLC22A11, rs2078267 | T | 0.77 (0.72–0.82), 3.12 × 10−17 | 0.92 (0.72–1.18), 0.51 | 0.15 | 0.75 (0.62–0.90), 2.74 × 10−3 | 0.73 | 0.86 (0.52–1.41), 0.54 | 0.85 |
Data are adjusted by age, sex, body mass index, hypertension, renal failure, and heart failure.
↵^ Interaction Pdetermined using an SNP by diuretic interaction term with comparison to no diuretic use. Experiment-wide significance was defined as P< 0.005. SNP: single-nucleotide polymorphism.