Adjusted HR* with 95% CI of radiographic and AUSCAN pain state transitions in participants with diabetes mellitus (DM) or cardiovascular disease (CVD) compared to those without DM or CVD.
| Type of Transition | State Transition | DM vs No DM n1 [DM])/n2 [no DM] aHR (95% CI) | CVD vs No CVD n1 [CVD])/n2 [no CVD] aHR (95% CI) |
|---|---|---|---|
| Incident GOGO rHOA | (A) No GOGO rHOA and low AUSCAN Pain → | 14/63 | 20/57 |
| (B) GOGO rHOA and low AUSCAN Pain | 1.01 (0.51–1.99) | 0.76 (0.45–1.26) | |
| (C) No GOGO rHOA and high AUSCAN Pain → | 2/20 | 13/9 | |
| (D) GOGO rHOA and high AUSCAN Pain | † | 1.58 (0.64–3.93) | |
| Worsening AUSCAN pain | (A) No GOGO rHOA and low AUSCAN Pain → | 36/87 | 52/71 |
| (C) No GOGO rHOA and high AUSCAN Pain | 0.97 (0.55–1.71) | 0.99 (0.63–1.55) | |
| (B) GOGO rHOA and low AUSCAN Pain → | 11/25 | 13/23 | |
| (D) GOGO rHOA and high AUSCAN Pain | 5.08 (1.38–18.77) ‡ | 1.08 (0.39–3.01) | |
| Improvement in AUSCAN pain | (C) No GOGO rHOA and high AUSCAN Pain → | 34/92 | 54/72 |
| (A) No GOGO rHOA and low AUSCAN Pain | 0.87 (0.53–1.41) | 0.58 (0.36–0.92) ‡ | |
| (D) GOGO rHOA and high AUSCAN Pain → | 7/13 | 6/14 | |
| (B) GOGO rHOA and low AUSCAN Pain | 4.48 (0.92–21.89) | 0.13 (0.02–0.77) ‡ |
Arrows indicate transition from 1 state to another. Each transition type (column 1) shows 2 state transitions.
↵* Adjusted for static (age, sex, race, education level) and time-varying (BMI, sxKOA, NSAID use) covariates.
↵† aHR and 95% CI not estimable because of small sample size.
↵‡ Statistically significant. Low AUSCAN pain = AUSCAN pain score ≤ 6; high AUSCAN pain = AUSCAN pain score > 6. aHR: adjusted HR; AUSCAN: Australian Canadian Osteoarthritis Hand Index; GOGO rHOA: radiographic hand osteoarthritis according to the Genetics of Generalized Osteoarthritis (GOGO) study35.