Table 4.

Patient-reported outcomes in flaring vs non-flaring^* patients across all followup timepoints.

Characteristics	Month 3			Month 6			Month 9			Month 12
Characteristics	Flare, n = 8	No Flare, n = 72	p	Flare, n = 8	No Flare, n = 65	p	Flare, n = 9	No Flare, n = 66	p	Flare, n = 15	No Flare, n = 62	p
Flare questionnaires
FLARE-RA total score (0–10)
	5.6 (2.8)	1.8 (1.6)	0.001	4.5 (2.5)	1.7 (2)	0.002	5.2 (2.8)	1.8 (1.9)	0.001	4.7 (2.3)	1.5 (1.8)	< 0.0001
RA-FQ total score (0–50)
	29 (12.3)	11.5 (9.3)	< 0.0001	25.3 (13.6)	10.5 (9.6)	0.002	24.4 (14.6)	10.8 (9.8)	0.003	22.6 (11.7)	8.6 (7.7)	< 0.0001
RA-FQ flare domains
Pain	6.6 (2.8)	2.5 (2.1)	< 0.0001	5.9 (2.8)	2.3 (2.1)	0.001	5.6 (2.6)	2.2 (2)	0.001	5.3 (2.6)	1.5 (1.5)	< 0.0001
Function	5.9 (3.1)	2.2 (2.1)	0.002	5.9 (2.8)	1.9 (1.9)	< 0.0001	4.6 (3.2)	2.0 (2.2)	0.009	4.5 (2.6)	1.7 (1.6)	< 0.0001
Fatigue	6.1 (2.9)	2.8 (2.5)	0.002	4.4 (3.4)	2.7 (2.6)	0.11	4.7 (3.2)	2.7 (2.4)	0.055	4.6 (2.9)	2.4 (2.3)	0.007
Stiffness	5.5 (2.8)	2.3 (2)	0.002	5.3 (3.1)	2.1 (2.2)	0.006	4.8 (3.1)	2.2 (2)	0.009	4.7 (2.6)	1.7 (1.7)	< 0.0001
Participation	5.6 (2.6)	1.8 (1.9)	0.001	3.9 (3.4)	1.7 (2.2)	0.031	4.9 (2.8)	1.8 (2.1)	0.001	3.6 (2.4)	1.3 (1.7)	0.002
Patient-reported joints
TJC28	4.1 (4.5)	2.1 (3.3)	0.02	7.3 (7.5)	2.4 (4.6)	0.003	8.6 (6.6)	1.7 (3.4)	< 0.0001	5.4 (6.3)	1.5 (4)	< 0.0001
SJC28	3.6 (4.4)	1.1 (2.5)	0.001	5.6 (6.9)	0.9 (2.2)	0.003	5.1 (7.8)	0.4 (1.2)	< 0.0001	3.9 (4.5)	0.5 (1.4)	< 0.0001

↵* Based on the question “Are you experiencing a flare of your RA at this time?” (yes/no). Values are mean (SD) unless otherwise specified. FLARE-RA: Flare Assessment in Rheumatoid Arthritis questionnaire; RA-FQ: OMERACT (Outcome Measures in Rheumatology) Rheumatoid Arthritis Flare Questionnaire; TJC28: tender joint count in 28 joints; SJC28: swollen joint count in 28 joints.