Table 4.

Factors associated with progression of CKD (time-dependent multivariate analysis).

VariablesHRLower 95% CIHigher 95% CIp
Simple time-dependent Cox regression (univariate)
  SLEDAI-2K1.081.021.150.011
  Anemia (Hb < 12 g/l)2.071.113.870.023
  Systolic BP1.021.0011.0350.038
  Prednisone dose (for 1 mg/day increase)1.0331.0151.0510.0003
  CKD 4 (compared to CKD 3b)2.4581.344.510.004
Multivariate time-dependent Cox regression
  Prednisone dose (for 1 mg/day increase)1.051.031.07< 0.0001
  CKD 4 (compared to CKD 3b)2.951.535.690.001
  Treatment with ACEI/ARB0.390.20.770.007
  • CKD: chronic kidney disease; Hb: hemoglobin; SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; Hb: hemoglobin; BP: blood pressure; ACEI: angiotensin-converting enzyme inhibitors; ARB: angiotensin receptor blockers.