Variables | SLE | General Medicaid | ||||||
---|---|---|---|---|---|---|---|---|
N | Events | PY | IR* (95% CI) | N | Events | PY | IR* (95% CI) | |
All patients | 46,876 | 121 | 89,494 | 1.4 (1.1–1.6) | 187,504 | 241 | 333,216 | 0.7 (0.6–0.8) |
18–39 yrs | 21,139 | 27 | 39,789 | 0.7 (0.5–1.0) | 84,461 | ‡ | ‡ | 0.1 (< 0.1–0.1) |
40–49 yrs | 12,552 | 29 | 24,153 | 1.2 (0.8–1.7) | 50,340 | 42 | 91,389 | 0.5 (0.3–0.6) |
50–65 yrs | 13,185 | 65 | 25,552 | 2.5 (2.0–3.2) | 52,703 | 191 | 98,665 | 1.9 (1.7–2.2) |
Sex | ||||||||
Female | 43,482 | 106 | 83,296 | 1.3 (1.1–1.5) | 173,928 | 210 | 309,555 | 0.7 (0.6–0.8) |
Male | 3394 | 15 | 6198 | 2.4 (1.5–4.0) | 13,576 | 31 | 23,661 | 1.3 (0.9–1.9) |
Hypertension | ||||||||
No | 29,558 | 44 | 56,138 | 0.8 (0.6–1.1) | 159,156 | 136 | 280,572 | 0.5 (0.4–0.6) |
Yes | 17,318 | 77 | 33,356 | 2.3 (1.9–2.9) | 28,348 | 105 | 52,644 | 2.0 (1.6–2.4) |
Valvular disease | ||||||||
No | 43,838 | 102 | 83,720 | 1.2 (1.0–1.5) | 184,878 | 219 | 328,700 | 0.7 (0.6–0.8) |
Yes | 3038 | 19 | 5773 | 3.3 (2.1–5.2) | 2626 | 22 | 4516 | 4.9 (3.2–7.4) |
LN/CKD | ||||||||
No | 37,789 | 74 | 69,972 | 1.1 (0.8–1.3) | 328,135 | 230 | 5081 | 0.7 (0.6–0.8) |
Yes | 9087 | 47 | 19,521 | 2.4 (1.8–3.2) | 5081 | 11 | 328,418 | 2.2 (1.2–3.9) |
CVD† | ||||||||
No | 39,352 | 69 | 75,415 | 0.9 (0.7–1.2) | 177,048 | 163 | 314,620 | 0.5 (0.5–0.6) |
Yes | 7524 | 52 | 14,079 | 3.7 (2.8–4.8) | 10,456 | 78 | 18,596 | 4.2 (3.4–5.2) |
Glucocorticoid use | ||||||||
No | 27,664 | 65 | 51,812 | 1.3 (1.0–1.6) | 176,722 | 223 | 315,156 | 0.7 (0.6–0.8) |
Yes | 19,212 | 56 | 37,682 | 1.5 (1.2–1.9) | 10,782 | 18 | 18,060 | 1.0 (0.6–1.6) |
↵* IR: per 1000 PY.
↵† CVD: baseline presence of any CVD by ICD-9 codes for angina, MI, old MI, percutaneous coronary intervention, atherosclerosis, cerebrovascular accident, coronary artery bypass graft, peripheral vascular disease, carotid stenosis, heart failure.
↵‡ Cell sizes under 11 are suppressed according to Federal Reporting Requirements. SLE: systemic lupus erythematosus; PY: person-years; IR: incidence rate; CVD: cardiovascular disease; CKD: chronic kidney disease; ICD-9: International Classification of Diseases, 9th revision; MI: myocardial infarction; LN: lupus nephritis.