Main characteristics of the 4 patients who developed cervical spine involvement at the 10-year followup.
| Characteristics | Patients | |||
|---|---|---|---|---|
| A | B | C | D | |
| FIN-RACo+PLA | FIN-RACo+IFX | FIN-RACo+IFX | FIN-RACo+IFX | |
| Baseline | ||||
| Age, yrs | 34 | 45 | 47 | 52 |
| Sex | Female | Male | Female | Female |
| RF | Positive | Positive | Positive | Positive |
| CRP, mg/l | 5 | 44 | 9 | 56 |
| HAQ | 0 | 0.75 | 1.00 | 1.62 |
| SvdH | 0 | 10 | 0 | 0 |
| At 10-year followup | ||||
| CRP, mg/l | < 3 | 4 | 5 | 39 |
| HAQ | 0.37 | 0 | 0.25 | 0.12 |
| SvdH | 22 | 12 | 3 | 3 |
| DMARD | Single csDMARD | Single csDMARD + bDMARD | Single csDMARD | Single csDMARD |
| Use of PSL | No | No | No | No |
| Cervical spine radiographs | SAS | AAS | AAI | AAS |
PLA: placebo; IFX: infliximab; RF: rheumatoid factor; CRP: C-reactive protein; HAQ: Health Assessment Questionnaire ; SvdH: Sharp/van der Heijde score; DMARD: disease-modifying antirheumatic drugs; csDMARD: conventional synthetic DMARD; bDMARD: biological DMARD; PSL: prednisolone; SAS: subaxial subluxation; AAS: atlantoaxial subluxation; AAI: atlantoaxial impaction.