Results of second kidney biopsy for LN cases.
| Results | 0 APOL1 RRA, n = 43 | 1 APOL1 RRA, n = 7 | 2 APOL1 RRA, n = 0 | p 0 vs ≥ 1 RRA |
|---|---|---|---|---|
| Proliferative lesion, % | 81.4 | 71.4 | 0.0 | 0.62 |
| Classes (overall test) | 0.28* | |||
| Class II | 1 (2.3) | 0 (0.0) | 0.0 | 1.00 |
| Class III (± V) | 15 (34.9) | 0 (0.0) | 0.0 | 0.09 |
| Class IV (± V) | 20 (46.5) | 5 (71.4) | 0.0 | 0.42 |
| Class V | 7 (16.3) | 2 (28.6) | 0.0 | 0.60 |
| Median no. glomeruli (25–75th) | 12 (8–16) | 18 (10–22) | 0.0 | 0.11 |
| Median global glomerular sclerosis (25–75th), % | 8.3 (0.0–28.2) | 4.0 (0.0–13.3) | 0.0 | 0.55 |
| Crescents | 10 (23.8) | 4 (57.1) | 0.0 | 0.09 |
| Median % crescents (25–75th), % | 0 (0–22) | 18.2 (5–75) | 0.0 | 0.03 |
| Synechia to BC | 24 (70.6) | 2 (40.0) | 0.0 | 0.31 |
| Fibrinoid necrosis | 2 (4.8) | 0 (0.0) | 0.0 | 1.00 |
| Hyaline thrombi | 6 (4.7) | 1 (14.3) | 0.0 | 1.00 |
| TMA | 2 (4.7) | 0 (0.0) | 0.0 | 1.00 |
| Membranous component | 26 (61.9) | 5 (71.4) | 0.0 | 1.00 |
| TIN | 4 (9.5) | 3 (42.9) | 0.0 | 0.05 |
| Tubular atrophy ≥ 25% | 13 (37.1) | 2 (33.3) | 0.0 | 1.00 |
| Interstitial fibrosis ≥ 25% | 16 (45.7) | 4 (66.7) | 0.0 | 0.41 |
| Mean ± SD activity index | 3.9 ± 2.8 | 5.7 ± 3.5 | 0.0 | 0.32 |
| Mean ± SD chronicity index | 4.4 ± 1.9 | 4.7 ± 0.6 | 0.0 | 0.80 |
↵* Chi-square test. Data are n (%) unless otherwise indicated. Data in bold face are statistically significant. LN: lupus nephritis; RRA: renal risk allele; BC: Bowman capsule; TMA: thrombotic microangiopathy; TIN: tubulointerstitial nephritis.