Table 3.

OR (95% CI) for the association of restless sleep (a single item) using the Center for Epidemiologic Studies Depression Scale (CES-D) with knee pain outcomes stratified by baseline widespread pain status in the Multicenter Osteoarthritis Study.

Knee Pain OutcomesRestless Sleep in Past Week in the CES-D
> 3–4 Days (Ref.)1–2 Days< 1 DayP Trend
Consistent frequent knee pain
  Cross-sectional association for prevalent consistent frequent knee pain, n = 4640
    Knee, n/N (%)1475/1050 (29.6)626/1948 (39.0)504/1642 (31.4)
    OR (95% CI)21.0 (ref)0.73 (0.60–0.89)0.76 (0.61–0.94)0.03
  Longitudinal association for incident consistent frequent knee pain, n = 2646
    Knee, n/N (%)122/497 (24.4)221/1178 (44.1)158/971 (31.5)
    OR (95% CI)1.0 (ref)0.91 (0.60–1.37)1.14 (0.70–1.84)0.35
Knee pain worsening, n = 4658
  Widespread pain absence, n = 2746
    Knee, n/N (%)81/434 (18.7)253/1174 (21.6)216/1138 (19.0)
    OR (95% CI)1.0 (ref)1.33 (0.93–1.91)1.11 (0.75–1.63)0.85
  Widespread pain presence, n = 1912
    Knee, n/N (%)222/618 (35.9)243/780 (31.1)157/514 (30.5)
    OR (95% CI)1.0 (ref)0.78 (0.59–1.02)0.73 (0.53–1.00)0.05
  • 1 No. knees: n (knees with pain worsening or incident joint pain) / N (total no. knees).

  • 2 Model adjusted for age (yrs), sex (men vs women), race (white vs non-white), study site, BMI (kg/m2), education level (college and above vs below college), tobacco use (pack-yrs), Charlson Comorbidity Index (range 0–9), fatigue (10-point scale), CES-D depression indicator (yes, no), and prescription use of NSAID (yes, no). BMI: body mass index; NSAID: nonsteroidal antiinflammatory drug.