Frequency of organ manifestations in all SLE patients versus in SSA/SSB-positive patients with SLE.
| SLE Manifestations | Missing Data, n | SLE Cohort, Ntotal = 504 (100%) | anti-Ro52+ NRo52+ = 140 (27.9%) | p | anti-Ro60+ NRo60 = 206 (41.3%) | p | anti-La/SSB+ NLa/SSB = 113 (22.6%) | p |
|---|---|---|---|---|---|---|---|---|
| Secondary SS | 0 | 117 (23.2) | 56 (47.9) | < 0.0001 | 69/117 (59.0) | < 0.0001 | 44 (37.6) | < 0.0001 |
| Malar rash | 0 | 246 (48.8) | 58 (41.4) | 0.04 | 103 (50.0) | 0.67 | 54 (47.8) | 0.78 |
| Discoid lesions | 0 | 88 (17.5) | 27 (19.3) | 0.52 | 46 (22.3) | 0.02 | 25 (22.1) | 0.14 |
| Photosensitivity | 0 | 318 (63.1) | 94 (67.1) | 0.26 | 142/201 (68.9) | 0.02 | 78/103 (69.0) | 0.14 |
| Oral ulcers | 2 | 168 (33.5) | 50 (35.7) | 0.46 | 68/201 (33.0) | 0.87 | 40/103 (35.4) | 0.58 |
| Arthritis | 1 | 406 (80.7) | 109 (77.9) | 0.33 | 161/201 (78.2) | 0.26 | 80/103 (70.8) | 0.002 |
| Pleuritis | 1 | 185 (36.8) | 53 (37.9) | 0.75 | 73/201 (35.4) | 0.61 | 48/103 (42.5) | 0.14 |
| Pericarditis | 1 | 88 (17.5) | 27 (19.3) | 0.48 | 33/201 (16.0) | 0.47 | 18/103 (15.9) | 0.63 |
| Nephritis | 1 | 202 (40.2) | 47/139 (33.8) | 0.07 | 72/205 (35.1) | 0.05 | 29/112 (25.9) | 0.0005 |
| Psychosis | 0 | 10 (2) | 2 (1.4) | 0.57 | 5 (2.4) | 0.57 | 1 (0.9) | 0.33 |
| Seizures | 0 | 49 (9.7) | 7 (5.0) | 0.02 | 15 (7.3) | 0.11 | 7 (6.2) | 0.14 |
| Leukopenia | 0 | 242 (48.0) | 77 (55.0) | 0.04 | 117 (56.8) | 0.0006 | 71 (62.8) | 0.0003 |
| Lymphopenia | 0 | 273 (54.2) | 85 (60.7) | 0.05 | 121 (58.7) | 0.06 | 70 (61.9) | 0.05 |
| Thrombocytopenia | 0 | 100 (19.8) | 25 (17.9) | 0.46 | 42 (20.4) | 0.79 | 23 (20.4) | 0.90 |
| RP | 0 | 195 (38.7) | 55 (39.3) | 0.87 | 82 (39.8) | 0.60 | 41 (36.3) | 0.57 |
| Vasculitis* | 6 | 57 (11.4) | 18/138 (13.0) | 0.50 | 31/203 (15.3) | 0.03 | 16/112 (14.3) | 0.29 |
| Interstitial lung disease | 0 | 24 (4.8) | 10 (7.1) | 0.12 | 10 (4.9) | 0.96 | 6 (5.3) | 0.76 |
| Peripheral neuropathy | 3 | 47 (9.4) | 15/139 (10.8) | 0.45 | 26/204 (12.7) | 0.02 | 13/112 (11.6) | 0.32 |
Numbers are given as ratios (no. positive/total no. tested) when measurements are missing. Values are n (%) unless otherwise specified. Values in bold face are statistically significant.
↵* All clinical vasculitis. SLE: systemic lupus erythematosus; SS: Sjögren syndrome; RP: Raynaud phenomenon; ILD: interstitial lung disease.