Demographic characteristics of records included in the systematic review.
| Study | Study Design | SSc Criteria | Sample Size, n = SSc/IPAH/HC | SSc-PAH/SSc-noPAH | Right Heart Catheterization Diagnosis of SSc-PAH (mPAP, PCWP, PVR) and Guidelines Followed by the Authors | NVC Assessment |
|---|---|---|---|---|---|---|
| Sulli, 2012, Italy30 | Longitudinal | (29a) | 38/0/0 | 4*/34 | mPAP > 25 mmHg. Other guidelines not stated | Videocapillaroscopy, 200× magnification |
| Avouac, 2017, France31 | Longitudinal | (18) | 140/0/0 | 8*/132 | mPAP ≥ 25 mmHg, PCWP ≤ 15 mmHg, 2009 ESC/ERS guidelines21 | Videocapillaroscopy, 200× magnification |
| Hofstee, 2009, Netherlands32 | Cross-sectional | (29a) | 40/20/21 | 21/19 | mPAP > 25 mmHg, 2004 ESC guidelines20 | Computer-based panorama mosaic videocapillaroscopy |
| Riccieri, 2013, Italy33 | Cross-sectional | (29a) | 24/0/0 | 12/12 | mPAP > 25 mmHg, 2009 ACCF/AHA guidelines22 | Videocapillaroscopy, 200× magnification |
| Corrado, 2017, Italy34 | Cross-sectional | (18) | 39/21/25 | 19/20 | mPAP ≥ 25 mmHg, PCWP ≤ 15 mmHg, PVR > 3 WU, 2015 ESC/ERS guidelines9 | Videocapillaroscopy, 200× magnification |
↵* Occurrence of incident SSc-PAH during followup period. ACCF: American College of Cardiology Foundation; AHA: American Heart Association; ERS: European Respiratory Society; ESC: European Society of Cardiology; HC: healthy controls; IPAH: idiopathic pulmonary arterial hypertension; mPAP: mean pulmonary arterial pressure; NVC: nailfold videocapillaroscopy; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; SSc: systemic sclerosis; SSc-noPAH: systemic sclerosis without PAH; SSc-PAH: systemic sclerosis–related PAH; WU: Wood units.